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Biomedical subjects

M Itsuno

Publications and source records attributed to M Itsuno.

24 records · Page 2Linked to original sources
PubMed1989

Multiple carcinoids and endocrine cell micronests in type A gastritis. Their morphology, histogenesis, and natural history.

Six cases of type A gastritis associated with multiple carcinoids and/or endocrine cell micronests (ECM) in the atrophic fundic mucosa were examined light microscopically, immunohistochemically, and ultrastructurally. The ECM and carcinoids were mainly composed of enterochromaffin-like (ECL) cells. The cells were hyperplastic only in the atrophic fundic glands and pseudopyloric glands, but not in the intestinal metaplastic gland. It is suggested that the development of both the ECM and the carcinoids is highly related to the atrophic change of the fundic mucosa and a trophic action of subsequently raised serum gastrin in type A gastritis and that the both lesions arise from the pseudopyloric glands or atrophic fundic glands. In addition, the definition of neoplastic ECM (microcarcinoid) of the stomach was made with comparative study on both the cases with ECM and multiple carcinoids and the cases with ECM alone.

Adult↗
PubMed1989

Clinical course and magnifying endoscopic findings of fine lesions of the large intestinal mucosa in Crohn's disease.

"Worm-eaten" appearance (WEA) is a fine lesion of Crohn's disease observed in apparently normal rectal mucosa by magnifying endoscopy. Magnifying endoscopy has now been performed following application of methylene blue on 37 occasions in 27 patients with Crohn's disease, and the occurrence of WEA was reviewed in relation to the duration and extent of disease. The frequency of WEA was 75% in patients with a history of less than five years and 77% in those who had had the disease for more than five years. In the active stage, the frequency was 85% and 100% respectively, and the degree of WEA also increased. The detection rate of granulomata in regions of WEA was 53% when the clinical history was less than five years and 33% when five years or more. In active disease, granulomata were found in 70% and 67% respectively. The large intestine other than the rectum was reviewed in eight patients with ileitis. WEA and granulomata were observed throughout the large intestine including the cecum, especially when the ileal disease was active.

Adult↗
PubMed1983

[Multiple gastric carcinoids occurring in atrophic fundic mucosa].

A 49-year-old man with iron deficiency anemia and achlorhydria was found to have a carcinoid 7 X 4 mm in the upper corpus of the stomach. The subtotally resected stomach histologically revealed 20 carcinoids measuring 0.1-7 mm in largest diameter and numerous argyrophil cell micronests at the base of the severely atrophic fundic mucosa. Some of the lesions invaded down to the submucosa. The antral mucosa was mildly atrophic. All carcinoids and micronests were non-argentaffin and argyrophil, and negative upon immunoreaction with 12 kinds of peptides and amine.

Atrophy↗