Biomedical subjects

M Iu

Publications and source records attributed to M Iu.

2 recordsLinked to original sources

PubMed1998

Solid-phase extraction method with high-performance liquid chromatography and electrochemical detection for the quantitative analysis of oxycodone in human plasma.

A sensitive and reproducible solid-phase extraction (SPE) method for the quantification of oxycodone in human plasma was developed. Varian Certify SPE cartridges containing both C8 and benzoic acid functional groups were the most suitable for the extraction of oxycodone and codeine (internal standard), with consistently high (> or =80%) and reproducible recoveries. The elution mobile phase consisted of 1.2 ml of butyl chloride-isopropanol (80:20, v/v) containing 2% ammonia. The quantification limit for oxycodone was 5.3 pmol on-column. Within-day and inter-day coefficients of variation were 1.2% and 6.8% respectively for 284 nM oxycodone and 9.5% and 6.2% respectively for 28.4 nM oxycodone using 0.5-ml plasma aliquots.

Analgesics, Opioid↗

PubMed1993

Pressure in plaster backslabs after surgery for ankle fractures.

Concern over the safety of applying a cast when postoperative swelling might be expected, prompted a study of the pressure inside backslabs. Using a modified Sengstaken tube, pressure measurements were taken from blackslabs applied for temporary support after open reduction and internal fixation of 15 ankle fractures. The mean pressure rise was 4.6 cmH2O (3.4 mmHg), the maximum increase in any cast was 18 cmH2O (13.2 mmHg), and the maximum pressure reached was 27.5 cmH2O (20.2 mmHg). There were no clinical signs or symptoms of excessive compression by the cast and in all cases the pressure had reached its maximum and begun to fall within 3 h of the operation. The ankle swelling associated with injury and surgery seems not to produce an unacceptable pressure rise within backslabs applied postoperatively.

Adult↗