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Biomedical subjects

M Iu Eropkin

Publications and source records attributed to M Iu Eropkin.

7 recordsLinked to original sources
PubMed1991

[A comparative analysis of the biological activity of an acid-extractable brain protein and fibroblast growth factors].

An acid-soluble protein was isolated from bovine brain tissue using a combination of 5% HClO4 acidic extraction, cation-exchange chromatography and heparin-Sepharose affinity chromatography. This preparation had a biological activity similar to that of the fibroblast growth factor (FGF). It has stimulated neurite outgrowth in organotypic culture of chicken embryo dorsal root ganglia and also has stimulated a proliferation of human embryonic fibroblasts in the culture. The biological activity of isolated preparation was totally inhibited by anti-bFGF antibodies, while anti-aFGF antibodies had no effect. The bFGF showed a neurite stimulating activity in the organotypic culture that was completely abolished by the anti-bFGF, IgG, while the aFGF was inactive. This data, as well as cationic properties of isolated protein and its heparin-binding ability, enable us to postulate a high degree of homology of the brain acid-soluble protein and the bFGF. At the same time the relations of the isolated growth factor and other brain-derived heparin-binding growth factors are yet to be established.

Animals↗
PubMed1978

[Effect of Freund's complete adjuvant on the catecholamine content in the adrenals and brain of white rats].

The authors studied the effect of a single subcutaneous injection of 0.3 ml of complete Freund's adjuvant on catecholamine content in the adrenal glands and the brain of Wistar rats. There proved to be a sharp reduction of adrenaline and noradrenaline content per gm of adrenal gland raw tissue, and per one adrenal gland at periods of from 1 to 5 weeks after the adjuvant administration, and also a loss of the adrenal gland weight. A less pronounced, but significant increase in the noradrenaline and DOPA concentration was revealed in the brain tissue during the first week after the adjuvant administration, and, of dopamine at all the periods of study. It is suggested that both the peripheral and central links of the sympathoadrenal system were activated by the nonspecific stimulant.

Adrenal Glands↗
PubMedDate not supplied

[Interrelationship between immunologic and neurologic memory: learning ability of rats during immunostimulation].

Studies have been made on the effect of an immunostimulator - the complete Freund's adjuvant - upon the learning ability in Wistar rats for visual discrimination using food-obtaining and avoidance of the electric shock techniques. Injection of the adjuvant significantly increases learning ability provided negative reinforcement technique is used, but inhibits the former under the conditions of positive reinforcement. Analysis of the extinction of the conditioned reflexes yielded similar results. Possible relation of immunogenesis to the formation of memory is discussed.

Animals↗