Biomedical subjects
Publications and source records attributed to M Iu Iakovlev.
The development of intestinal dysbacteriosis in white mice, caused by the administration of ampyox in large doses, was shown to be accompanied by a considerable decrease in cell-mediated and humoral antiendotoxin immunity, which was manifested by a decrease in the titers of antiendotoxin antibodies and in the content of polymorphonuclear leukocytes, capable of binding endotoxin.
The dependence of the quantitative content of Escherichia coli in the feces of newborn infants 3 days after birth on the titer of anti Re-glycolipid antibodies in umbilical blood and in mother milk was studied. The reverse correlation between the number of bacteria in feces and the titers of anti Re-glycolipid antibodies was established, the amount of bacteria depending more on antibody titers in umbilical blood than on those in mother milk. The conclusion was made that antiglycolipid antibodies played an important role in the regulation of the quantitative content of E. coli in the intestine of newborn infants. In case of the deficiency of such antibodies intestinal dysbacteriosis may develop in newborn infants.