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M Iwamura

Publications and source records attributed to M Iwamura.

79 records · Page 5Linked to original sources
PubMed1987

[Bilateral renal cell carcinoma: report of two cases].

Two cases of bilateral renal cell carcinoma are reported. The first case is of a 54-year-old male who visited our hospital on March 7, 1984 complaining of colicky pain in his left flank. Intravenous urography showed a large mass in the upper pole of the left kidney causing deformity and dislocation of the upper calyces. There were no remarkable findings in the right kidney. Abdominal CT-scan and arteriography revealed a round and hypervascular tumor with soft tissue mass density in the upper pole of both kidneys. Nephrectomy of the left and segmental resection of the upper pole of the right kidney were performed on April 11, 1984. The second case is a 47-year-old male who visited our hospital complaining of total gross hematuria. Intravenous urography showed a large soft tissue mass at the lower pole of the left kidney. Abdominal CT-scan revealed a large tumor mass associated with central necrosis in the left kidney and also a small tumor lesion at the center of the contralateral kidney. Bilateral nephrectomy was performed on December 19, 1984, and the patient was referred to hemodialysis treatment. The cut section of the nephrectomized right kidney specimen revealed multiple minor accessory tumors. Both patients have been doing well without any evidence of recurrence or metastasis.

Carcinoma, Renal Cell↗
PubMed1987

[A clinical study of testicular tumors].

Fifty-eight of the 44,698 patients seen at our Department, between 1972 and 1984 had a testicular tumor. The incidence rate was 0.13%. The mean age of these 58 cases was 28.6 years and two peak distributions, one in the 0 to 5 year and another in 26 to 30 year age group were observed. Among them, 54 patients (93.1%) had chief complaints of painless testicular swelling at initial examination. The vast majority of them had unilateral tumors; 28 in the right and 29 in the left. Only one patient had bilateral seminomas. Histologically, 30 of them (51.7%) were seminoma, 8 were embryonal carcinoma (13.8%), 2 were teratoma (3.5%) and the remaining 18 had tumors of double or multiple histological type. Most of the seminomas were treated by a combination of high orchiectomy and radiotherapy, and chemotherapy was done mainly for non-seminomatous cases. The 5-year survival rate calculated by the Kaplan-Meier method was 100% for patients with low stage (I, II) seminomas and 62% for those with non-seminomatous tumors.

Adolescent↗
PubMed1983

Drug-induced inhibition of guinea pig platelet aggregation unrelated to their beta-adrenolytic actions.

Inhibitory actions on adenosine diphosphate (ADP)-induced platelet aggregation of atenolol, dl- and d-D-32, IPS-339, pindolol and propranolol were investigated in guinea pigs for the purpose of obtaining a clue about a possible mechanism for the disaggregatory phenomenon of beta-adrenoceptor blocking agents. The effects of verapamil and procaine on guinea pig platelet aggregation were also examined. All of these agents including verapamil and procaine showed a dose-dependent inhibitory effect on platelet aggregation, and their relative potencies determined on the basis of the molar concentrations producing a 50% inhibition of ADP-induced aggregation were in descending order: IPS-339 greater than propranolol greater than verapamil greater than dl-D-32 not equal to d-D-32 greater than pindolol greater than procaine greater than atenolol. This order of relative potencies of the inhibitory actions of these test compounds on platelet aggregation was well correlated to those of local anaesthetic action in guinea pigs (r = 0.932, P less than 0.01) and lipophilicity (r = -0.899, P less than 0.01), while it did not agree with the orders of potency of beta-adrenoceptor blocking action, intrinsic sympathomimetic action and vasodilator action. From these results, it may be reasonable to propose that inhibitory actions of beta-adrenoceptor blocking agents and local anaesthetics on platelet aggregation are caused through the same mechanism or through a very similar one.

Adrenergic beta-Antagonists↗
PubMedDate not supplied

Immunoreactive parathyroid hormone-related protein is present in human seminal plasma and is of prostate origin.

Parathyroid hormone-related protein (PTHrP) is a regulatory peptide that has been associated with normal fetal growth and differentiation as well as the regulation of fetal calcium. We recently demonstrated the expression of PTHrP in neuroendocrine cells of human prostatic glands. The present study was undertaken to determine if semen contained PTHrP and to determine if there were any differences in seminal PTHrP between normal and vasectomized men. Radioimmunoassay was used to examine whether immunoreactive PTHrP in seminal fluid is secreted by the prostate. Significant quantities of immunoreactive PTHrP were detected in all seminal samples from normal men of ages 24-34 years (mean +/- SD, 12.94 +/- 8.2 ng/ml). Vasectomy did not decrease the semen levels of PTHrP (25.53 +/- 12.14 ng/ml). In addition, immunohistochemical evaluation with a monoclonal antibody used in our previous study did not show PTHrP immunostaining in the seminal vesicles. These findings indicate that seminal PTHrP is predominantly of prostatic origin. Moreover, the significant correlations between PTHrP and calcium levels in human seminal plasma from both normal (P < 0.001) and vasectomized (P < 0.02) patients suggest that PTHrP may serve as a regulatory factor of calcium secretion in the prostate.

Adult↗