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Biomedical subjects

M Iwatani

Publications and source records attributed to M Iwatani.

11 recordsLinked to original sources
PubMed2000

[Insulin sensitizer and urate metabolism].

Gout patients often have various characteristics of insulin resistance (IR) syndrome such as glucose intolerance, hyperlipidemia, hypertension and obesity. In addition, epidemiological data suggest that hyperuricemia is associated with higher rates of death due to cardiovascular and cerebrovascular disorders. However, it has not conclusively been shown whether the association between hyperuricemia and increased death rate is secondary to the association between IR and death or hyperuricemia itself is an independent risk of death. It is of interest to examine the effects of insulin sensitizer which was developed recently on serum urate concentration because it may provide a new idea as to the mechanism of the association between IR, hyperuricemia and vascular disorders. In the present paper, we discuss the relevance of IR to hyperuricemia and gout, and show the data of urate and glucose metabolism obtained from control subjects or the patients with hyperuricemia, gout or type 2 diabetes.

Chromans↗
PubMed1996

[Hyperuricemia and insulin resistance].

Hyperuricemia is often associated with obesity, hypertension and dyslipidemia, and is thought to be a risk factor for cardiovascular disease, thereby making resemblance to the insulin resistance syndrome. Our data showed a low, but significant correlation between serum uric acid concentration and the degree of insulin resistance (GIR) estimated by euglycemic hyperinsulinemic clamp method in 67 subjects with combined normal glucose tolerance and IGT(r = -0.278, p < 0.05). Plasma HDL-C and TG levels were also correlated with uric acid levels. One hundred sixty NIDDM patients who had undergone the clamp study were stratified into 5 groups according to the serum uric acid level. In the top quintile (UA : 7.8 +/- 0.8 mg/dl), BMI, male prevalence, plasma TG, HDL-C, fasting IRI, and total IRI response(0 + 60 + 120 min) during meal tolerance test were significantly higher, while age and GIR value tended to be lower without significance compared with those in the bottom quintile (UA : 3.4 +/- 0.5 mg/dl). These results, which are in agreement with the previous studies, support the notion that elevated serum uric acid is a feature of insulin resistance syndrome.

Cardiovascular Diseases↗
PubMed1993

[Hyperuricemia and atherosclerosis].

To clearly determine whether hyperuricemia participates directly in atherosclerotic disease or not, the prognosis and associated factors were studied, based on data from 104 patients whose serum uric acid had been completely maintained at normal levels with prolonged medication. The mean age at death was 65.8 +/- 10.5 years. The causes of death were as follows: cardiovascular disease (26.9%), cerebral disease (26.2%), malignant neoplasms (26.0%), uremia (7.6%), and miscellaneous disease (18.3%). Serum lipids especially triglycerides, body weight and influenced on the prognosis of the patients FBS. Most common complications were in the cardiovascular disease group; hypertension and hyperlipidemia. These data suggested that the apparent increased incidence of cardiovascular disease in gout rather than renal failure bore a relationship to such complications as hypertension or hypertriglycemia. Hyperuricemia alone may not be an atherosclerotic risk factors. There was no correlation between treatment with allopurinol and probenecid and cardiovascular complications.

Aged↗
PubMed1985

Thermographic evaluation of the hemodynamic effect of the antithrombotic drug cilostazol in peripheral arterial occlusion.

Cilostazol (6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2(1H)-quinolinone, OPC-13013) was evaluated experimentally to be effective in increasing blood flow in arterial occlusive disease. The hemodynamic effect of the drug on peripheral arterial occlusion was examined using a non-invasive thermographic technique over a certain period of time. The study included 10 patients with peripheral arterial occlusion, 7 with thromboangiitis obliterans and 3 with arteriosclerosis obliterans. Cilostazol was administered at 200 mg/day for 6 successive weeks to 7 patients (10 lower limbs and 1 upper limb) and at 100 mg/day for 6 weeks to 2 patients (3 lower limbs) and 4 weeks to 1 (1 lower limb), and the skin temperature and skin blood flow were measured in the limbs of these patients. The 200-mg/day dose brought about elevation of the two parameters at 4 and 6 weeks. The increase in skin temperature in the leg and foot at 6 weeks was statistically significant (p less than 0.05, t-test), and the increase in skin blood flow was also significant in the leg (p less than 0.05) and foot (p less than 0.1). Such increase was obtained at the lower dose of 100 mg/day, but the number of cases was too small to statistically analyze patient response.

Aged↗
PubMed1983

Plasma amino acid levels in hyperosmolar nonketotic diabetic coma.

The plasma amino acid levels in five patients with hyperosmolar nonketotic diabetic coma and in seven normal subjects were analysed. In the patients with hyperosmolar nonketotic diabetic coma, total amino acids were generally low, especially, the concentrations and the molar ratios of arginine, taurine and serine were significantly low, and ornithine decreased only at the concentration. The level of phenylalanine increased both at the concentration and the molar ratio, and tyrosine did only at the molar ratio. The significance of such changes in the plasma is discussed in relation to diabetic ketoacidosis or lactic acidosis.

Amino Acids↗