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Biomedical subjects

M J Ackerman

Publications and source records attributed to M J Ackerman.

9 recordsLinked to original sources

Optical technology: making the simulator portable.

Optical disc technology can be either analog or digital. Analog (videodiscs) simulation programs are available for the allied health professions educator to incorporate into the curriculum. Digital optical discs, currently available in three formats, follow standards that have been adopted by the International Standards Organization. The formats differ in the amount of information they can accommodate and their practical use in the health professions curriculum.

Computer Simulation

Two novel cardiac atrial K+ channels, IK.AA and IK.PC.

Two K(+)-selective channels in neonatal rat atrial cells activated by lipophilic compounds have been characterized in detail. The arachidonic acid-stimulated channel (IK.AA) had a slope conductance of 124 +/- 17 pS at +30 mV in symmetrical 140 mM potassium and a mean open time of approximately 1 ms, and was relatively voltage independent. IK.AA activity was reversibly increased by lowering pH to 6.0. Arachidonic acid was most effective in activating this channel, although a number of lipophilic compounds resulted in activation. Surprisingly, choline, a polar molecule, also activated the channel. A second K+ channel was activated by 10 microM phosphatidylcholine applied to the intracellular surface of inside-out atrial patches. This channel (IK.PC) had a slope conductance of 60 +/- 6 pS at +40 mV and a mean open time of approximately 0.6 ms, and was also relatively voltage independent. Fatty acids are probably monomeric in the membrane under the conditions of our recording; thus detergent effects are unlikely. Since a number of compounds including fatty acids and prostaglandins activated these two channels, an indirect, channel-specific mechanism may account for activation of these two cardiac K+ channels.

Animals

New media in medical education.

In 1984 the American Association of Medical Colleges' Panel on the General Professional Education of the Physician challenged the medical community to take a leadership position in the effective application of information science and computer technology to medical education. The medical education community has risen to that challenge through the use of microcomputer technology and optical disc media including the recently developed fully integrated Hypermedia environment to enhance the learning environment.

Audiovisual Aids

Calculation of the relative speed of sound in a gas mixture.

Since the frequency spectrum of a voice signal is directly dependent on the velocity of sound, studies of speech spectra include the problem of calculating the speed of sound in the gas mixture being used. A computer program written in BASIC has been developed to calculate the speed of sound relative to air in various diving gas mixtures. In addition, a set of tables available as a separate technical report has been generated using this program. These tables are designed to provide a standard reference for reporting spectral shifts in speech due to different gas mixtures under normal diving conditions.

Computers