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M J Alsar Ortiz

Publications and source records attributed to M J Alsar Ortiz.

8 recordsLinked to original sources
PubMed1993

[Oxidative hepatic metabolism in chronic alcoholics during the acute abstinence period: evaluation with antipyrine elimination].

In chronic alcoholics, while they consume ethanol, an increase in the oxidative hepatic metabolism is produced by means of an increment of microsomal enzymes induced by ethanol. In our study we have appraised this hepatic metabolism during the period of acute ethilic abstinence. This study has been performed in 20 chronic alcoholics without clinical symptoms, after five days free of ethanol drinks. The assessment of oxidative hepatic metabolism was realized by means of the measuring of corporal antipyrine clearance (by saliva elimination), being compared to those performed in a control group of ten healthy adults. Antipyrine clearance (5.5 +/- 2 l/h) is increased significatively in chronic alcoholics respect to the control group value (3.4 +/- 1 l/h) (p < 0.01). Elimination half-life of antipyrine in chronic alcoholic groups (7.6 +/- 3 h) is decreased significatively respect to the control group value (11.2 +/- 2 h) (p < 0.01). During the period of acute abstinence, the oxidative hepatic metabolism persists increased. In these patients, when we administer drugs with hepatic metabolism following the same metabolic way that antipyrine, it will be necessary to readjust the maintenance dose to attain its therapeutic effect.

Adult↗
PubMed1992

[The assessment of liver microsomal oxidative capacity via caffeine and antipyrine elimination in patients with chronic active hepatitis: preliminary results].

The hepatic metabolism of drugs in patients with chronic active hepatitis has been studied in a few occasions, finding discordant results. In our preliminary study we pretend to appraise the microsomal oxidative hepatic metabolism in 10 chronic active hepatitis HBs Ag(+) outpatients without clinical symptoms. The concentrations of both substances were measured in saliva and the caffeine and antipyrine tests of these patients were compared to control group. The difference found in the caffeine and antipyrine elimination, between the chronic active hepatitis group and the control group, have been low, without statistics significance (p > 0.1). Although, the results are preliminaries and is necessary to follow this study in many patients, probably the caffeine and antipyrine elimination are not decreased in the chronic active hepatitis without clinical symptoms. In these patients, the microsomal oxidative hepatic metabolism is not altered.

Adult↗