Biomedical subjects

M J Butson

Publications and source records attributed to M J Butson.

At least 19 recordsLinked to original sources

PubMed2006

Scanning orientation effects on Gafchromic EBT film dosimetry.

Gafchromic EBT film, a new high sensitivity radiochromic film has been tested for variations in optical properties due to scanning orientation. Gafchromic EBT film has been shown to produce a scanning orientation effect whereby variations in measured relative optical density are found due to the films orientation relative to the scanner direction. This relative optical density change was found to be relatively consistent for different films exposed to varying dose levels ranging from 0 Gy to 3 Gy. A maximum variation of 0.0157 +/- 0.0035 in optical density (OD) was found. This relates to an approximate 15% variation in net OD for a 50 cGy irradiated film and 4% variation for a 3 Gy irradiated film. No noticeable effects or variations were seen with changing scanning resolution or with the film placed "up or down" during scanning. Other Gafchromic film types were tested and compared to EBT for unirradiated film to assess the magnitude of this orientation effect on the scanner used and results showed that EBT produced a significantly higher effect that MD-55-2, HS, XR type T and XR type R film by up to 3 times. As such, providing the same orientation of EBT film when scanning for dosimetric analysis becomes an essential part of EBT film dosimetry.

Anisotropy↗

PubMed2005

Absorption spectra variations of EBT radiochromic film from radiation exposure.

Gafchromic EBT radiochromic film is one of the newest radiation-induced auto-developing x-ray analysis films available for therapeutic radiation dosimetry in radiotherapy applications. The spectral absorption properties in the visible wavelengths have been investigated and results show two main peaks in absorption located at 636 nm and 585 nm. These absorption peaks are different to many other radiochromic film products such as Gafchromic MD-55 and HS film where two peaks were located at 676 nm and 617 nm respectively. The general shape of the absorption spectra is similar to older designs. A much higher sensitivity is found at high-energy x-rays with an average 0.6 OD per Gy variation in OD seen within the first Gy measured at 636 nm using 6 MV x-rays. This is compared to approximately 0.09 OD units for the first Gy at the 676 nm absorption peak for HS film at 6 MV x-ray energy. The film's blue colour is visually different from older varieties of Gafchromic film with a higher intensity of mid-range blue within the film. The film provides adequate relative absorbed dose measurement for clinical radiotherapy x-ray assessment in the 1-2 Gy dose range which with further investigation may be useful for fractionated radiotherapy dose assessment.

Dose-Response Relationship, Radiation↗

PubMed2004

Prostate dosimetry in an anthropomorphic phantom.

Four field prostate treatments are a standard treatment procedure in radiotherapy. Dose in the prostate and rectum region were calculated for 6MV and 18MV photon beams on an anthropomorphic phantom with a collapsed cone convolution method using a 3-D planning system. Validation has been performed with radiographic film and thermoluminescent dosimeters. Results have shown that the pinnacle planning system has accurately modelled doses delivered to a heterogeneous phantom with calculations and measurements agreeing within +/-3% over most areas. When treating clinically, considerations such as the volume of bowel gas should be taken into account when planning. A sample of patient CT scans showed that in the absence of a heterogeneity correction, the error in estimated dose through the rectum could be as high as 8% in the presence of large volumes of rectal gas. Considerations, such as whether the patient undergoes another CT scan, the bowel gas volume ignored or assigned a specific density needs to be taken into account and brought to the attention of the radiation oncologists for accurate treatment.

Humans↗

PubMed2003

Variations in skin dose using 6MV or 18MV x-ray beams.

This research aimed to quantitatively evaluate the differences in percentage dose of maximum for 6MV and 18MV x-ray beams within the first 1 cm of interactions. Thus provide quantitative information regarding the basal, dermal and subcutaneous dose differences achievable with these two types of high-energy x-ray beams. Percentage dose of maximum build up curves are measured for most clinical field sizes using 6MV and 18MV x-ray beams. Calculations are performed to produce quantitative results highlighting the percentage dose of maximum differences delivered to various depths within the skin and subcutaneous tissue region by these two beams. Results have shown that basal cell layer doses are not significantly different for 6MV and 18MV x-ray beams. At depths beyond the surface and basal cell layer there is a measurable and significant difference in delivered dose. This variation increases to 20% of maximum and 22% of maximum at 1 mm and 1 cm depths respectively. The percentage variations are larger for smaller field sizes where the photon in phantom component of the delivered dose is the most significant contributor to dose. By producing graphs or tables of % dose differences in the build up region we can provide quantitative information to the oncologist for consideration (if skin and subcutaneous tissue doses are of importance) during the beam energy selection process for treatment.

Dose-Response Relationship, Radiation↗

PubMed2003

MOSFET dosimetry in-vivo at superficial and orthovoltage x-ray energies.

This note investigates in-vivo dosimetry using a Metal Oxide Semiconductor Field Effect Transistor (MOSFET) for radiotherapy treatment at superficial and orthovoltage x-ray energies. This was performed within one fraction of the patients treatment. Standard measurements along with energy response of the detector are given. Results showed that the MOSFET measurements in-vivo agreed with calculated results on average within +/- 5.6% over all superficial and orthovoltage energies. These variations were slightly larger than TLD results with variations between measured and calculated results being +/- 5.0% for the same patient measurements. The MOSFET device provides adequate in-vivo dosimetry for superficial and orthovoltage energy treatments with the accuracy of the measurements seeming to be relatively on par with TLD in our case. The MOSFET does have the advantage of returning a relatively immediate dosimetric result after irradiation.

Equipment Design↗

PubMed2003

Polarity effect on surface dose measurement for an attix parallel plate ionisation chamber.

The effects of chamber polarity have been investigated for the measurement of 6MV and 18MV x-ray surface dose using a parallel plate ionization chamber. Results have shown that a significant difference in measured ionization is recorded between polarities at 6MV and 18MV at the phantom surface. A polarity ratio ranging from 1.062 to 1.005 is seen for 6MV x-rays at the phantom surface for field sizes 5 cm x 5 cm to 40 cm x 40 cm when comparing positive to negative polarity. These ratio's range from 1.024 to 1.004 for 18MV x-rays with the same field sizes. When these charge reading are compared to the Dmax readings of the same polarity it is found that these polarity effects are minimal for the calculation of percentage dose results with variations being less than 1% of maximum.

Equipment Failure Analysis↗

PubMed2003

Variations in 6MV x-ray radiotherapy build-up dose with treatment distance.

Dose in the build up region for high energy x-rays produced by a medical linear accelerator is affected by the x-ray source to patient surface distance (SSD). The use of isocentric treatments whereby the tumour is positions 100 cm from the source means that depending of the depth of the tumour and the size of the patient, the SSD can vary from distances of 80 cm to 100 cm. To achieve larger field sizes, the SSD can also be extended out to 120 cm at times. Results have shown that open fields are not significantly affected by SSD changes with deviations in percentage dose being less than 4% of maximum dose for SSD's from 80 cm to 120 cm SSD. With the introduction of beam modifying devices such as Perspex blocking trays, the effects are significant with a deviation of up to 22% measured at 6MV energy with a 6 mm Perspex tray for SSD's from 80 cm to 120 cm. These variations are largest at the skin surface and reduce with depth. The use of a multi leaf collimator for blocking removes extra skin dose caused by the Perspex block trays with decreasing SSD.

Humans↗

PubMed2001

Spatial resolution of a stacked radiochromic film dosimeter.

PURPOSE: The spatial resolution of stacked radiochromic film dosimeters, which have increased sensitivity from a single layer radiochromic film detector, has been studied. METHODS: A 5-layer film which can easily be constructed provided a 4.3-times increase in sensitivity over a single layer film at 670 nm readout wavelength which meant that doses as low as 0.6 Gy could be measured with an accuracy of +/-4% with the stacked dosimeter. The spatial resolution was tested by comparison of the 80%/20% penumbral widths of a 5 x 5 cm 6 MV X-ray field. RESULTS: The MD-55-2 film measured the penumbral width as 3.0 mm whereas the 5-layer stack dosimeter measured the same penumbra as 3.2 mm. CONCLUSION: The stack dosimeter can provide useful in vivo information such as the position of a diverging beam edge for treatments around critical structures such as eyes during the first fraction of treatment.

Film Dosimetry↗

PubMed2001

Radiochromic film dosimetry in water phantoms.

Radiochromic film is investigated for use in dosimetry in water phantoms as opposed to solid phantoms. Investigations are performed to measure the penetration rates of water into radiochromic film and to assess the effects on optical density that this penetration causes. The effects of film orientation during irradiation in water are also tested. Results show that only a small penetration rate is seen from water into the film which only affects the outer areas of the film, with penetration being less than 0.5 mm per hour. The optical density measurements of the film at 660 nm remain unchanged in the unaffected regions of the radiochromic film. Minimal effects are seen due to beam orientation in a water phantom as opposed to solid water phantoms in which an overestimation in dose is normally seen for parallel irradiation. Radiochromic film seems to be an adequate detector for dosimetry in a water phantom where high spatial resolution is needed and angle of beam incidence at the point of interest is important.

Dose-Response Relationship, Radiation↗

PubMed2001

Visible dye light absorption properties of processed radiographic film.

The visible absorption spectra of Kodak X-Omat V film, which had been exposed to various doses of radiation, have been investigated to analyse the dosimetry characteristics of the film with various densitometers. Common densitometers can use fluorescent light (broad band visible), helium-neon (632 nm) or other spectra of specific bandwidth. The visible absorption spectra show a slight peak in absorption at approximately 580 nm and another at 630 nm caused by the base material of the film. The optical density of the film is shown to increase almost equally at all wavelengths within the visible region with increases in applied dose. By evaluating the results for the broad band spectra and specific wavelength optical density it is shown that a relatively uniform response is expected for all densitometers that work within the visible region as well as in selected infrared wavelengths. Thus similar optical density to dose response curves for X-Omat V radiographic film should be produced for all types of densitometers, no matter what type of light source is used for illumination. Thus it is most efficient to have a densitometer with a light source suitable for radiochromic film, which can also be used with radiographic film.

Absorption↗

PubMed2000

Assessment of large single-fraction, low-energy X-ray dose with radiochromic film.

PURPOSE: To investigate the accuracy of in vivo dosimetry using radiochromic film for large single-fraction, low-energy irradiations. METHODS AND MATERIALS: Gafchromic MD-55-2 radiochromic film and LiF thermoluminescent dosimeters (TLDs) were placed in vivo on 25 patients to ascertain their effectiveness for assessment of dose. All patients received 10 Gy single fractions at energies ranging from 100 kVp (half-value layer [HVL] = 3.5 mm Al) up to 250 kVp (HVL = 2.3 mm Cu). Effects of small air gaps were also investigated using LiF TLDs and radiochromic film. RESULTS: Radiochromic film adequately measured applied dose for 25 patients in vivo with a standard deviation of 5.5% from prescribed dose. LiF TLDs recorded a standard deviation of 4.1% from measured to applied dose. Small air gaps which can be created under the film or TLDs during in vivo dosimetry were shown to have a measurable but minimal effect on results for gaps less than 5 mm. CONCLUSIONS: Gafchromic film has adequately measured applied dose in vivo at low energy for large 10 Gy single-fraction irradiation.

Fluorides↗

PubMed2000

Blood irradiation with accelerator produced electron beams.

Blood and blood products are irradiated with gamma rays to reduce the risk of graft versus host disease (GVHD). A simple technique using electron beams produced by a medical linear accelerator has been studied to evaluate irradiation of blood and blood products. Variations in applied doses for a single field 20 MeV electron beam are measured in a phantom study. Doses have been verified with ionization chambers and commercial diode detectors. Results show that the blood product volume can be given a relatively homogeneous dose to within 6% using 20 MeV electrons without the need to rotate the blood bags or the beam entry point. The irradiation process takes approximately 6.5 minutes for 30 Gy applied dose to complete as opposed to 12 minutes for a dual field x-ray field irradiation at our centre. Electron beams can be used to satisfactorily irradiate blood and blood products in a minimal amount of time.

Blood↗

PubMed2000

Verification of lung dose in an anthropomorphic phantom calculated by the collapsed cone convolution method.

Verification of calculated lung dose in an anthropomorphic phantom is performed using two dosimetry media. Dosimetry is complicated by factors such as variations in density at slice interfaces and appropriate position on CT scanning slice to accommodate these factors. Dose in lung for a 6 MV and 10 MV anterior-posterior field was calculated with a collapsed cone convolution method using an ADAC Pinnacle, 3D planning system. Up to 5% variations between doses calculated at the centre and near the edge of the 2 cm phantom slice positioned at the beam central axis were seen, due to the composition of each phantom slice. Validation of dose was performed with LiF thermoluminescent dosimeters (TLDs) and X-Omat V radiographic film. Both dosimetry media produced dose results which agreed closely with calculated results nearest their physical positioning in the phantom. The collapsed cone convolution method accurately calculates dose within inhomogeneous lung regions at 6 MV and 10 MV x-ray energy.

Algorithms↗

PubMed2000

Measurement of radiotherapy x-ray skin dose on a chest wall phantom.

Sufficient skin dose needs to be delivered by a radiotherapy chest wall treatment regimen to ensure the probability of a near surface tumor recurrence is minimized. To simulate a chest wall treatment a hemicylindrical solid water phantom of 7.5 cm radius was irradiated with 6 MV x-rays using 20x20 cm2 and 10x20 cm2 fields at 100 cm source surface distance (SSD) to the base of the phantom. A surface dose profile was obtained from 0 to 180 degrees, in 10 degrees increments around the circumference of the phantom. Dosimetry results obtained from radiochromic film (effective depth of 0.17 mm) were used in the investigation, the superficial doses were found to be 28% (of Dmax) at the 0 degrees beam entry position and 58% at the 90 degrees oblique beam position. Superficial dose results were also obtained using extra thin thermoluminescent dosimeters (TLD) (effective depth 0.14 mm) of 30% at 0 degrees, 57% at 90 degrees, and a metal oxide semiconductor field effect transistor (MOSFET) detector (effective depth 0.5 mm) of 43% at 0 degrees, 62% at 90 degrees. Because the differences in measured superficial doses were significant and beyond those related to experimental error, these differences are assumed to be mostly attributable to the effective depth of measurement of each detector. We numerically simulated a bolus on/bolus off technique and found we could increase the coverage to the skin. Using an alternate "bolus on," "bolus off" regimen, the skin would receive 36.8 Gy at 0 degrees incidence and 46.4 Gy at 90 degrees incidence for a prescribed midpoint dose of 50 Gy. From this work it is evident that, as the circumference of the phantom is traversed the SSD increases and hence there is an inverse square fluence fall-off, this is more than offset by the increase in skin dose due to surface curvature to a plateau at about 90 degrees. Beyond this angle it is assumed that beam attenuation through the phantom and inverse square fall-off is causing the surface dose to reduce.

Breast Neoplasms↗

PubMed1999

Dosimetry of blood irradiation with radiochromic film.

It has been shown that radiochromic film is an ideal dosimeter for assessment and verification of delivered dose to irradiated blood products. Using a parallel opposing two-field technique on a medical linear accelerator, blood is irradiated to diminish the risk of transfusion-associated graft vs. host disease (TA-GVHD). The blood products are irradiated in a Perspex blood box to an applied dose of 29.5-31.7 Gy. Verification of applied dose has been performed with thimble ionization chambers and radiochromic film. Radiochromic film results have matched absorbed dose measurements from ionization chambers at all sites within the 'active' treatment volume within +/-6% for a 95% confidence limit. Using a sample of 100 in-vitro measurements, radiochromic film has measured the average applied dose to blood products to be 30.95+/-2.6 Gy for two standard deviations. Like currently available 'irradiated' film labels, the radiochromic film also serves as a visible reminder that the blood products have been irradiated.

Blood↗

PubMed1999

Comparison of effective source-surface distances for electron beams derived from measurements made under different scatter conditions.

The purpose of this paper is to investigate the effect of scatter conditions around the chamber on the effective source-surface distance (SSDeff) calculation. Three setups were considered, viz with the chamber: in air, in solid water at the surface, and in solid water at dmax. Ionization measurements for electron beams from a Varian Clinac-210 degrees C were recorded from 100 cm to 120 cm nominal SSD in 5 cm increments, using a parallel-plate Markus chamber. Two electron energies, 6 and 12 MeV, were investigated with a range of electron applicators (Series-III, 10 x 10 to 25 x 25 cm2) and different cerrobend inserts (square and rectangular). The study was undertaken by placing the chamber in air and in solid water, respectively. SSDeff was calculated from the ionisation chamber measurements using the method of Khan (1984). The results are summarised in the table 1. In almost all cases the SSDeff calculated using the in-air data is less. This is likely to be due to a larger proportion of scatter off the applicators reaching the chamber when it is in air than when it is at dmax in the phantom. The results also show the difference is reduced for a larger applicator, probably because the applicator scatter component reaching the in-air measurement point is reduced.

Particle Accelerators↗

PubMed1998

Effects of read-out light sources and ambient light on radiochromic film.

Both read-out light sources and ambient light sources can produce a marked effect on coloration of radiochromic film. Fluorescent, helium neon laser, light emitting diode (LED) and incandescent read-out light sources produce an equivalent dose coloration of 660 cGy h(-1), 4.3 cGy h(-1), 1.7 cGy h(-1) and 2.6 cGy h(-1) respectively. Direct sunlight, fluorescent light and incandescent ambient light produce an equivalent dose coloration of 30 cGy h(-1), 18 cGy h(-1) and 0 cGy h(-1) respectively. Continuously on, fluorescent light sources should not be used for film optical density evaluation and minimal exposure to any light source will increase the accuracy of results.

Calibration↗

PubMed1998

Measurement of off-axis and peripheral skin dose using radiochromic film.

A radiotheraphy skin dose profile can be obtained with radiochromic film. The central axis skin dose relative to Dmax for a 10 x 10 cm2 field size was found to be 22%, 17% and 15.5% for 6 MV, 10 MV and 18 MV photon beams. Peripheral dose increased with increasing field size. At 10 MV the skin dose 2 cm outside the geometric field edge was measured as 6%, 10% and 17% for 10 x 10 cm2, 20 x 20 cm2 and 30 x 30 cm2 field sizes respectively. Off-axis skin dose decreased as distance increased from central axis for fields with Perspex block trays. For a 20 x 20 cm2 field, an approximately 5-8% drop in percentage skin dose was observed from central axis to the beam edge.

Biophysical Phenomena↗