PubMed Health⌕ Search

Biomedical subjects

M J Campion

Publications and source records attributed to M J Campion.

At least 19 recordsLinked to original sources
PubMed1998

Vulvar intraepithelial neoplasia and carcinoma.

This report describes the classification, clinical profile, etiology, and management of high-grade squamous vulvar intraepithelial-neoplasia (VIN). Recent studies have better defined the progressive potential of high-grade VIN and the relationship of such lesions to squamous vulvar carcinoma. The histologic classification and descriptions have undergone significant refinement over the past decade. The increasing use of more conservative therapeutic approaches to high-grade VIN has demanded greater expertise in clinical evaluation to ensure invasive disease is not missed or undertreated.

Carcinoma in Situ↗
PubMed1996

Clinical manifestations and natural history of genital human papillomavirus infections.

Over the past decade, the ever-increasing volume of evidence implicating HPV types in genital neoplasia has stimulated much research interest into all aspects of the biology of this interesting group of viruses. This research has led to the identification of growing heterogeneity of HPV types. It is not surprising, therefore, that the clinical profile of disease associated with genital HPV types is much broader than previously recognized. Knowledge of this clinical spectrum is mandatory to the understanding of the possible role of specific HPV types in human carcinogenesis.

Condylomata Acuminata↗
PubMed1994

Omental herniation through a 5-mm laparoscopic cannula site.

Herniation is a rare complication of laparoscopy, and has not previously been reported to occur through a 5-mm puncture site. A patient experienced an incarcerated omental prolapse through an incision for a 5-mm cannula 4 days after undergoing a laparoscopic radical hysterectomy. Based on our experience, we recommend fascial closure of all laparoscopic cannula insertion sites if possible, and emphasize the need for evaluating omental or enteric protrusions through even small fascial defects.

Adult↗
PubMed1993

Cervicography as an adjunct to cytologic screening.

Cervicography is not a surrogate for colposcopy. Its easy availability and economy maximize the predictive potential of the existing screening test, the Pap smear. It can also be used as a triage tool for women "at risk" for cervical HPV infections, such as women with a history of vulvar condylomata. It is not colpophotography, as the magnification and focus are stable, and the operator cannot manipulate the position of the cervix and change focus and light settings. Cervicography cannot replace Pap smears in detection programs, but can augment the predictive value of screening when used in tandem. Stafl cautions gynecologic practitioners to use the two in partnership and that the duo can push cervical cancer detection rates closer to 100%. What Cervicography does provide is a screening tool with great potential and a way to attack the troubling death rates from cervical cancer still facing us in the 21st century.

Adult↗
PubMed1993

Colposcopy in pregnancy.

The management of the abnormal smear in pregnancy remains a challenge to the modern colposcopist. Colposcopy in pregnancy is difficult. Anatomic variants can mimic disease. Significant cytologic overall detection of low-grade squamous intraepithelial lesions demands an increased understanding of physiologic variants in pregnancy. Possible recent increases in cervical cancer incidence in younger women requires comprehensive knowledge of warning signs of early invasion. Modern management approaches must temper the need for accurate exclusion of cancer with the risk of overly aggressive interference in patients without disease or with very minor atypia.

Biopsy↗
PubMed1991

Clinical manifestations and natural history of genital human papillomavirus infection.

Over the past decade, the ever-increasing volume of evidence implicating HPV types in genital neoplasia has stimulated much research interest into all aspects of the biology of this interesting group of viruses. This has led to the identification of an ever-increasing heterogeneity of HPV types. It is not surprising, therefore, that the clinical profile of disease associated with genital HPV types is much broader than previously recognized. Knowledge of this clinical spectrum is mandatory to the understanding of the possible role of specific HPV types in human carcinogenesis.

Anus Neoplasms↗
PubMed1991

Vaginal laser surgery.

Vaginal epithelial lesions including endometriosis, cysts, septae, human papillomavirus (HPV) disease, and vaginal intraepithelial neoplasia (VaIN) can be successfully treated by laser surgery. The carbon dioxide laser with a wavelength of 10,600 nm is the ideal laser for these clinical applications. Pretreatment evaluation using colposcopically directed biopsies is mandatory. Adherence to surgical techniques including the selection of a delivery system, control of thermal injury, depth of destruction and bleeding, as well as determination of treatment margins and therapeutic endpoints are critical for optimal clinical outcome. After treatment of HPV disease and VaIN, long-term follow-up is essential for this group of patients who are at risk for invasive cancer.

Carcinoma in Situ↗
PubMed1990

Screening for gynecologic cancer.

Screening principles, methods, and terminology are discussed for cervical, endometrial, and ovarian cancers. Incidence and mortality, risk factors, adjuncts to screening, and historic perspectives are also covered.

Adult↗
PubMed1988

The modified radical vulvectomy with groin dissection: an eight-year experience.

Fifty-one patients were admitted to a single practice at St. Joseph's Hospital between April 1, 1978, and April 1, 1986 with a diagnosis of squamous cell carcinoma of the vulva greater than 1 mm in depth. Five advanced lesions were treated with combinations of radiation and surgery. Four patients had recurrent squamous cell carcinoma. Of 42 patients treated surgically with intention of cure, 14 were treated with complete radical vulvectomy and bilateral inguinofemoral lymphadenectomies, and 28 patients were treated with complete radical vulvectomy and bilateral inguinofemoral lymphadenectomies, and 28 patients were treated in 26 instances with bilateral inguinofemoral lymphadenectomies in one of five different excision patterns individualized to the site of primary tumor. None of the 28 patients have had a recurrence. Five had positive nodes. Eight have died of unrelated causes. Lesions in 25 cases were stage I or II and in three cases they were stage III. Modified radical vulvectomy and bilateral groin dissection is a safe approach for most patients with stage I or II and occasionally even stage III lesions.

Aged↗
PubMed1988

Psychosexual trauma of an abnormal cervical smear.

The psychosexual sequelae of diagnosis and treatment of pre-invasive cervical atypia were assessed in three groups of women. The first group included 30 women referred to a colposcopy clinic with an abnormal cervical smear indicating cervical intraepithelial neoplasia (CIN), the second comprised 50 women who were traced as sexual partners of men with penile human papillomavirus (HPV) infection; 26 of them had histologically proven cervical atypia and 24 had no such evidence. The third group included 25 women traced as partners of men with non-specific urethritis and who did not have cervical disease. Before and after questionnaires assessed six aspects of sexual behaviour and responses before diagnosis and 6 months after treatment in women with cervical atypia. These were compared with answers given by women investigated and treated, if necessary, as partners of men with sexually transmitted disease (control group). There were statistically significant adverse psychosexual sequelae associated with diagnosis and treatment of pre-invasive cervical epithelial disease.

Adult↗
PubMed1988

Subclinical penile human papillomavirus infection and dysplasia in consorts of women with cervical neoplasia.

Fifty men whose sexual partners were 50 women with histologically proved cervical intraepithelial neoplasia (CIN) grade III (severe dysplasia or carcinoma in situ) were studied. A further 25 men whose current regular sexual partners were 25 women with chlamydial cervicitis were recruited as controls. If either of the partners in either group had genital condylomata acuminata or a known history of similar lesions, the couple was excluded from the study. Abnormal penile epithelium, which was detected by colposcopy after application of 5% acetic acid to the penile skin, was reported in 25 men in the study group compared with three in the control group. Histologically proved subclinical penile infection with human papillomavirus (HPV) was present in 23 men in the study group compared with three in the control group (p less than 0.01). Of the 50 men in the study group, four had histologically proved severe penile dysplasia or carcinoma in situ with evidence of HPV infection, the disease being subclinical in each case and diagnosed on histology of a specimen obtained by colposcopically directed biopsy. HPV DNA was detected on filter hybridisation of penile scrapes from 15 of the 23 men in the study group with histologically proved penile HPV infection, HPV16 DNA being detected in 10 of them. HPV DNA was detected on DNA-DNA hybridisation of biopsy material in seven of 18 men with histologically proved penile HPV infection. Five of these biopsy specimens were positive for HPV16 DNA. Only one man in the control group had HPV DNA detected in a penile scrape. This patient had histologically proved subclinical penile HPV infection. Such lesions may represent an important male reservoir of HPV types implicated in genital squamous carcinogenesis in both sexes.

Adult↗