Hypothyroidism in patients with Down syndrome.
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Biomedical subjects
Publications and source records attributed to M J Carlyle.
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This population-based, retrospective cohort study of very low birth weight infants was undertaken to: 1) identify factors associated with nonattendance for follow-up, 2) estimate the prevalence of cerebral palsy at age > or = 18 months, and 3) model the prognostic association between prenatal and perinatal risk markers and cerebral palsy. The sample included 496 surviving very low birth weight infants born in 32 hospitals in Southwest Ontario between January 1982 and December 1986. Multivariate analyses were performed using the proportional odds regression model. Loss to follow-up was more likely among those with mothers < 20 years of age, those with unmarried mothers, and those not born in a tertiary center. Loss to follow-up was less likely for those with neonatal anemia and those of lower birth weight. Motor development of the 369 children who were followed at least 18 months was classified into one of three categories: normal, suspect, or cerebral palsy. Multivariate analysis revealed that factors predictive of poorer outcome were intraventricular hemorrhage, unmarried mother, male sex, recurrent apnea, and hydrocephalus. The finding that unmarried status was associated with loss to follow-up and was also an important predictor of cerebral palsy suggests that it is important for follow-up clinics to identify ways of assisting this population to remain in contact with the clinic.
The principal idea expressed in this paper is that there is a period of time between the birth of a child with a severe handicap and the realization of the parents that the child may need their specific individual attention to his general development because of that handicap: that this coincides with the period of time usually taken by doctors for diagnosis of all the aspects contributing to the developmental delay; that these periods are both likely to be two to three years. Intervention by a competent developmental therapist working weekly in the home is of specific aid to the infant, to the parents and to the doctor during this period.
An effort has been made to influence the development of severely handicapped infants and improve the quality of life for their families in one health care district. Weekly visits to the homes by a 'developmental therapist' for 2 years after the initial suspicion of major developmental delay have taken place. The visits have been carried out by senior professional staff in the therapeutic professions who normally deal with a young handicapped population working within a closely knit team directed by a paediatrician and a psychologist. Success and difficulties met by children, families, therapists and team are described. Appreciation of the child's individual characteristics and his family's particular accommodation to them has been the task of therapists, who appear to have successfully crossed the parent-professional barrier. Evaluation of maternal attitudes in this group and a comparison group from another health care district is being carried out. This paper is the first of three. The next two will describe the observed effects in the children and the families respectively.