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Biomedical subjects

M J Chambers

Publications and source records attributed to M J Chambers.

8 recordsLinked to original sources

Actigraphy and insomnia: a closer look. Part 1.

In recent years, wrist actigraphy has been scrutinized as a possible supplement to or even replacement for other methods traditionally used to assess the sleep of clinical patients and research subjects. While showing promise for some applications, its accuracy in measuring the nocturnal sleep of insomniacs remains in question. A reexamination of the relevant data indicates that with respect to estimating the total sleep time of insomnia patients, use of the actigraph does not yield significantly lower error than daily sleep logs and predicts only about a third of the variance. However, the actigraph does show some potential for assessing the night-to-night variability of a given individual's sleep, suggesting that it may be most useful for assessing longitudinal changes within a treatment program or experimental protocol.

Arousal

The role of state-trait anxiety in insomnia and daytime restedness.

This study examined the relationships among anxiety, nocturnal sleep, and daytime restedness over a 1-week period, using the Spielberger State-Trait Anxiety Inventory and daily sleep logs. Among both insomniacs and controls, between-subjects correlations showed a significant negative relationship between state anxiety at bedtime and restedness during the day. Neither variable was related to nocturnal sleep variables. Within-subject correlations showed similar relationships between state anxiety and restedness the following day. For insomniacs, but not for normal sleepers, bedtime state anxiety was also significantly correlated with sleep latency. The authors hypothesize that anxiety, not sleep deprivation, may be responsible for the insomniac's complaint of daytime fatigue.

Adult

Assessment and prediction of outcome for a brief behavioral insomnia treatment program.

This study examined (a) the efficacy, and (b) predictors of outcome of a brief (one to four sessions) behavioral treatment program for chronic insomnia. A total of 103 insomnia patients were treated, and outcome was assessed by a follow-up questionnaire. Outcome variables, including both nocturnal sleep parameters and measures of daytime functioning, showed significant improvement subsequent to treatment. Pretreatment sleep hygiene practices were significantly correlated with daytime fatigue and sleep latency outcome factors. Pre- and post-treatment complaints of daytime fatigue were associated with somatic complaints in general, but not with nocturnal sleep variables. Explanatory hypotheses are discussed.

Adult

Prolactin induces its own receptors in rat liver.

Attempts to restore PRL receptors (PRL-R) in liver membranes of hypophysectomized rats with injections of PRL have so far been only partly successful. In the present study, bovine PRL (bPRL) was mixed with polyvinylpyrrolidone (PVP) in order to sustain PRL blood levels with a single injection a day. PRL-R were measured by displacement of the binding of [125I]ovine PRL (lactoperoxidase oxidation) to a 5000 x g particulate fraction of liver by unlabeled ovine PRL. The number of binding sites was calculated by Scatchard analysis and expressed as femtomoles per mg protein. PRL-R were 85 +/- 12 fmol/mg in normal intact female rats. Seven days posthypophysectomy, PRL-R were undetectable. Daily injections of bPRL with PVP for 10 days fully restored PRL-R (117 +/- 32 fmol/mg). No significant change in PRL-R was noted when bPRL was injected with bovine GH (bGH; 120 +/- 23 fmol/mg), bovine LH (bLH; 84 +/- 14 fmol/mg), bGH plus bLH (90 +/- 12 fmol/mg), or estrogens (79 +/- 12 fmol/mg). Daily injections of bGH or bLH, alone or in combination, or estrogens with PVP failed to restore PRL-R. These results demonstrate a direct role of PRL in stimulating the production of its own receptors when a sustained blood level of the hormone is achieved.

Animals

Professional dietetic education in the U.S. Historical notes.

Since its founding in 1917, The American Dietetic Association has been concerned with the development and improvement of educational programs for the professional dietitian. This article traces the evolution of professional dietetic educational programs from its beginning in the early cooking schools in the nineteenth century through the development of educational standards, the requirement for training beyond the bachelor's degree, and the establishment of academic requirements. The continued importance of educating the professional dietitian is evidenced by the inclusion of academic requirements as a prerequisite to membership in the Association.

Curriculum

Assessing achievement for minimum academic competency. I. Instrument development.

Test instruments for evaluating The American Dietetic Association's Minimum Academic Competencies were developed and tested for four major instructional areas--food, nutrition, nutrition in disease, and management--relevant to professional sciences for general dietetics. The study consisted of four steps: Development of objectives or test criteria; determination of mastery performance standards; test instrument development; and test administration and evaluation. This paper describes procedures used in developing and testing two forms of a criterion-referenced test instrument, which was then administered to determine academic competency of students in dietetics. Salient findings of the test results and evaluation are reported.

Dietetics

Assessing achievement for minimal academic competency. II. Validity and reliability.

Research was undertaken to develop, administer, and evaluate two forms of a criterion-referenced test instrument for measuring the competency status of students graduating from undergraduate programs in general dietetics. Involved in the evaluation of the final forms were 186 students graduating from fourteen college or university programs. Results are reported on the content validity, concurrent validity, reliability, and summary and individual test-item statistics. It is concluded that the test forms need further refinement and development and that the use of criterion-referenced evaluation tools to measure academic competency of students graduating in dietetics is needed.

Dietetics