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Biomedical subjects

M J Chusid

Publications and source records attributed to M J Chusid.

97 records · Page 6Linked to original sources
PubMedDate not supplied

Effect of prophylactic colchicine therapy on leukocyte function in patients with familial Mediterranean fever.

Patients with familial Mediterranean fever (FMF) who were part of a double-blind trial of daily colchicine as prophylaxis for their disease had leukocyte functions studied while receiving colchicine or placebo. Leukocytes taken from these patients while on prophylactic doses of colchicine produced normal quantities of leukocytic pyrogen, ingested bacteria normally, and migrated normally in chemotatic chambers. In addition these patients had normal numbers of circulating T and B lymphocytes as well as normal blastogenic reponses of their peripheral lymphocytes to mitogenic stimuli. The patients on colchicine, however, had significantly fewer neutrophils and monocytes accumulating at skin-window sites 24 hours after the initial abrasion. Because the early phase of the skin-window response was normal in these patients, the decreased late response may be related to a failure to amplify the initial inflammatory reaction. The reduced capacity to generate a normal inflammatory response may account for the failure of these patients to develop full attacks while taking colchicine.

Cell Migration Inhibition↗
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"Campylobacter upsaliensis" sepsis in a boy with acquired hypogammaglobulinemia.

A 16-year-old boy with lupus erythematosus and hypogammaglobulinemia developed bacteremia with "Campylobacter upsalinesis," a recently described Campylobacter species with minimal catalase activity. Because "C. upsaliensis" Gram stains poorly and because it is susceptible to antibiotics in standard selective media, it may be overlooked in routine handling of blood cultures.

Adolescent↗
PubMedDate not supplied

Microbiological tolerance in orthopaedic infections: delayed response of septic arthritis and osteomyelitis of the hip due to infection with tolerant Staphylococcus aureus.

A 14-year-old boy presented to another hospital with a clinical picture of septic arthritis. After aspiration of purulent material from the joint, empiric antibiotic treatment was initiated and an arthrotomy was performed. Antibiotic treatment was then modified to nafcillin according to microbiological sensitivity results of the isolated Staphylococcus aureus as determined by minimal inhibitory concentration testing. One week later purulent drainage recurred and open drainage had to be repeated; an abscess anterior to the joint was noted. Once again the infection failed to resolve, and the patient was transferred to our institution where a third arthrotomy had to be performed. The organism isolated at the first aspiration was reexamined and found to have a minimal bactericidal concentration to minimal inhibitory concentration ratio of 32, implying a tolerant organism. The antibiotic treatment was modified to an antibiotic not subject to the tolerance phenomenon, and the infection resolved without additional surgical intervention.

Adolescent↗
PubMedDate not supplied

Prevalence of penicillin resistant and multi-drug resistant Streptococcus pneumoniae at a children's hospital.

Streptococcus pneumoniae isolated at Children's Hospital of Wisconsin during the winter of 1994 to 1995 and the winter of 1996 to 1997 were tested for susceptibility to penicillin, cephalosporins and other potentially therapeutically useful antimicrobial agents to determine the prevalence of penicillin and multi-drug resistant isolates. During those years, the prevalence of S. pneumomiae not susceptible to penicillin was 27% and 28%, respectively, with 14% and 18%, respectively, of the respiratory isolates being high-level penicillin resistant. Despite the stable numbers of penicillin resistant isolates, there was evidence of significant increase in the resistance of these isolates to other antimicrobial agents. Respiratory isolates not susceptible to cefotaxime increased (p = .01; Fisher exact test) from 3% in 1995 to 20% in 1997. There was also a significant increase in the isolates not susceptible to erythromycin (p = .09; Fisher exact test) and trimethoprim/sulfamethoxazole (p < .01; Fisher exact test). This increase in resistance to multiple antimicrobial agents has significant implications for antibiotic therapy of children with infections likely to be due to Streptococcus pneumoniae.

Child↗
PubMedDate not supplied

Alpha omega alpha election and medical school thesis publication: relationship to subsequent publication rate over a twenty-year period.

To determine the importance of academic and research success during medical school upon subsequent academic activity, a computerized literature search was performed using the names of the 79 surviving members of the Yale Medical School Class of 1970. Individuals elected to Alpha Omega Alpha (AOA) during the third year of school had significantly more publications (mean 101.7 +/- 69.6) between 1970 and 1990 than those elected during the fourth year (mean 28.3 +/- 48.0, p = 0.01). Both had significantly more publications than non-AOA members (mean 11.1 +/- 19.4, p = 0.02). Publication of the student's medical school thesis was also associated with a greater number of publications than thesis non-publication (mean 22.1 +/- 37.5 vs 14.4 +/- 30.0, p = 0.005). These studies demonstrate that, at least at the institution studied, election to AOA and publication of the results of a research project were associated with increased publication rates in the medical field over the 20-year period following medical school graduation.

Academic Dissertations as Topic↗