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Biomedical subjects

M J Clyman

Publications and source records attributed to M J Clyman.

17 recordsLinked to original sources

Appearance of tonofilaments and absence of microtubules in human endometrial glandular epithelium. A function of estrogen activity.

In 1966, Cavazos et al.(1) carried out electron-microscopic studies of human endometrium and reported the presence of microtubules in glandular epithelial cells. This study presents evidence that no microtubules are evident at any stage of the menstrual cycle. Instead, there are numerous tonofilaments that increase in number, forming bundles that relate to the formation of new desmosomes. They are under the influence of both endogenous and exogenous estrogen and dissipate under the influence of progesterone. This feature may be of submicroscopic importance in stabilizing the rigidity of cells prior to preparation for nidation under the influence of progesterone.

Cytoskeleton↗

Agranular membrane complexes in certain smooth-muscle cells of the lamina propria of the human oviduct. An electron-microscope study.

Electron-microscopic examination of 40 tubal specimens from 28 patients revealed the unexpected presence of considerable numbers of smooth-muscle cells in the lamina propria. These "fibromuscular" cells (FM) are branched and have irregular contours; others resemble fibrocytes. All have the identifying features of smooth-muscle cells: from 50 to 75 A filaments with scattered densities, plasmalemmal thickenings, and basement lamina. A prominent smooth-muscle complex (SMC) is associated with certain of these smooth-muscle cells. They are located in all three segments of the tube and concentrated in the 10 cell layers subjacent to the epithelium. These complexes resemble structures in a variety of steroid-synthesizing cells and may possibly play a comparable role in the oviduct.

Adult↗