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Biomedical subjects

M J Daily

Publications and source records attributed to M J Daily.

14 recordsLinked to original sources

Retained nuclei after cataract surgery.

The authors reviewed the medical records of 36 patients in whom the nucleus or nuclear fragments were retained in the eye after cataract surgery. In 4 patients, there was no further surgery, and visual acuity deteriorated to counting fingers or worse (mean follow-up time, 14 months). Thirty-two patients underwent vitrectomy to remove the retained, unencapsulated nuclear material. Sixty percent (6 of 10) of patients in whom vitrectomy was performed after 3 weeks had chronic glaucoma on long-term follow-up, whereas this complication developed in only 18% (4 of 22) of patients in whom vitrectomy was performed in less than 3 weeks. Sixty-three percent (21 of 32) of vitrectomy patients had final visual acuity of 20/200 or better after removal of the retained nuclear fragments. The causes of the poorest visual outcome (less than 20/200) included 1 or more of the following: corneal decompensation, chronic inflammation, chronic glaucoma with optic atrophy, and retinal detachment.

Aged

Endogenous Candida endophthalmitis after intravenous anesthesia with propofol.

Propofol is an intravenous anesthetic agent that was approved by the US Food and Drug Administration in October 1989. It has gained rapid acceptance and is in widespread use. In June 1990, the Centers for Disease Control reported four clusters of postsurgical infections associated with the use of propofol. We describe one of those clusters, consisting of four cases of endogenous Candida albicans endophthalmitis. These infections occurred in nonimmunocompromised patients after they had undergone nonophthalmologic surgery in which propofol had been used as anesthesia. An investigation by the Centers for Disease Control concluded that the infections in these patients were due to extrinsic contamination of propofol during preparation for use at the hospital. Ophthalmologists should be aware of this new potential source of endogenous endophthalmitis.

Anesthesia, Intravenous

Presumed intraocular nocardiosis in a cardiac-transplant patient.

A 44-year-old cardiac-transplant patient receiving immunosuppressive therapy developed a chorioretinal mass OS. The lesion was consistent with an ocular nocardial infection. The patient also developed a testicular abscess that was shown to contain N. asteroides after orchiectomy. Despite appropriate systemic treatment, the patient developed extensive subretinal scarring OS. This case report is the first to describe an opportunistic ocular infection with N. asteroides after cardiac transplantation.

Adult

Multiple evanescent white-dot syndrome. A report of eight cases.

Multiple evanescent white-dot syndrome (MEWDS) is a newly described clinical disease entity. The authors report on eight patients with findings characteristic of this syndrome. All of the patients were women and relatively young, with an average age of 28.2 years. Patients complained of unilateral black spots in their vision, with an initial visual acuity of 20/25 to 20/60. Examination showed characteristic small, white dots at the level of the retinal pigment epithelium (RPE). Fluorescein angiography demonstrated patchy hyperfluorescent defects at the level of the RPE with some late staining. All patients had good recovery of visual acuity with eventual fading of the white dots.

Adult

Treatment of proliferative diabetic retinopathy with panretinal cryotherapy.

Panretinal cryoablation was performed on 100 eyes with retinal neovascularization and vitreous hemorrhage. Of those 100 eyes, 70 had neovascularization and recurrent hemorrhage despite previous panretinal laser photocoagulation, and 30 eyes had media opacities precluding laser treatment. Sixty applications, random and focal, were placed in each eye. Forty-six percent of eyes achieved better visual acuity, 32% were unchanged, and 22% were worse. Eighty-three percent of eyes had vision of 20/200 or better. In eyes without prior laser photocoagulation, 83% were clear of vitreous hemorrhage following cryoablation, and in eyes with previous panretinal photocoagulation, 75% were free of vitreous hemorrhage after cryoablation.

Adult

Subretinal neovascularization with geographic (serpiginous) choroiditis.

Three patients with geographic choroiditis developed subretinal neovascular membranes associated with subretinal hemorrhage and serous elevation of the retina. Proximity of the membrane to the foveal avascular zone prevented photocoagulation of the neovascular membrane in one patient. Central visual acuity remained 6/60 (20/200) despite systemic corticosteroid therapy. The neovascular membranes in the other two patients were obliterated by argon laser photocoagulation with preservation of central vision. The inflammatory process of geographic choroiditis can disrupt Bruch's membrane, allowing occasional choroidal vascular growth. Concomitant destruction of choroidal vessels may account for rarity of subretinal neovascularization in geographic choroiditis.

Aged