Biomedical subjects

M J Del Baño

Publications and source records attributed to M J Del Baño.

3 recordsLinked to original sources

PubMed2006

Radioprotective-antimutagenic effects of rosemary phenolics against chromosomal damage induced in human lymphocytes by gamma-rays.

The radioprotective effects of carnosic acid (CA), carnosol (COL), and rosmarinic acid (RO) against chromosomal damage induced by gamma-rays, compared with those of L-ascorbic acid (AA) and the S-containing compound dimethyl sulfoxide (DMSO), were determined by use of the micronucleus test for antimutagenic activity, evaluating the reduction in the frequency of micronuclei (MN) in cytokinesis-blocked cells of human lymphocytes before and after gamma-ray irradiation. With treatment before gamma-irradiation, the most effective compounds were, in order, CA > RO > or = COL > AA > DMSO. The radioprotective effects (antimutagenic) with treatment after gamma-irradiation were lower, and the most effective compounds were CA and COL. RO and AA presented small radioprotective activity, and the sulfur-containing compound DMSO lacked gamma-ray radioprotection capacity. Therefore, CA and COL are the only compounds that showed a significant antimutagenic activity both before and after gamma-irradiation treatments. These results are closely related to those reported by other authors on the antioxidant activity of the same compounds, and the degree of effectiveness depends on their structure. Furthermore, the results for treatments before and after gamma-ray irradiation suggest the existence of different radioprotective mechanisms in each case.

Abietanes↗

PubMed2001

Improved water solubility of neohesperidin dihydrochalcone in sweetener blends.

Significant technological advantages in terms of sweetness synergy and hence cost-saving can be obtained if neohesperidin dihydrochalcone (NHDC) is used in sweetener blends with other intense or bulk sweeteners. The combination of NHDC with sodium saccharin or sodium cyclamate is an excellent method to improve the water solubility at room temperature of NHDC. In the case of NHDC-sodium saccharin, two different methods for blend preparation, a simple mixture and a cosolubilized mixture, can be used, with similar results obtained for solubility and solution stability properties. To improve temporally the water solubility of NHDC in combination with sodium cyclamate, it is absolutely necessary to prepare cosolubilized blends.

Chalcone↗

PubMed1993

Risk factors associated with inguinal hernias: a case control study.

OBJECTIVES: To assess reported risk factors for the development of inguinal hernias, to develop a method of quantifying physical effort, and to correlate them. DESIGN: Case control study. SETTING: District hospital, Valencia, Spain. SUBJECTS: 290 selected patients who had undergone inguinal hernia repair, and 290 age and sex matched controls. INTERVENTIONS: Each patient was interviewed and data collected on a specially designed questionnaire, and an "effort score" calculated. MAIN OUTCOME MEASURES: Incidence of specified risk factors. RESULTS: The only significant risk factor was physical effort (lifting heavy objects repeatedly over long periods of time), relative risk 2.92, 95% confidence interval 2.11 to 4.04. In addition, there were significant differences between index cases and controls in standard of education (p < 0.001), consumption of alcohol (p = 0.02), chronic cough (p < 0.001), net monthly income (p = 0.04), and amount of physical effort expended (p < 0.001). Patients with indirect hernias expended significantly more physical effort and were both heavier and taller, and patients with femoral hernias waited significantly longer than the others before having their hernias repaired. CONCLUSION: Inguinal hernias are associated with the expenditure of a considerable amount of physical effort, and are commoner among younger, poorly educated manual workers.

Adult↗