Drug development through the genetic engineering of antibiotic-producing microorganisms.
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Anti-Bacterial Agents↗
Biomedical subjects
M J Donovan
Publications and source records attributed to M J Donovan.
The genetic and biochemical basis of polyketide metabolism in microorganisms and its role in drug discovery and development.
The possibilities for the design of new drug screening and development strategies directed to a specific objective on the basis of genetic engineering of microorganisms is discussed from two points of view. Firstly, results of work on genetic hybrids of Streptomyces species for the production of new metabolites such as mederrhodin (1) and aloespanoarin II (4) are described. Secondly, the enhanced production of known metabolites such as tetracenomycin A2 (11) and tetracenomycin C (9) by recombinant Streptomyces species is considered. Mechanistic aspects of polyketide metabolism are included.
Acetates↗
Temporal experience and motor behavior among the aging.
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Age Factors↗
A follow-up study of the reliability and validity of the motor activity rating scale.
This study compared and extended the evaluation of reliability and validity of the Motor Activity Rating Scale (MARS) for observing and symbolically recording body positions, body movements, and intensity of body movements. In contrast to a previously reported study, the movement of relatively inactive individuals was observed. High interrater reliability and statistically significant correlations between MARS movement scores and actometer scores were again observed.
Aged↗