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Biomedical subjects

M J Fairman

Publications and source records attributed to M J Fairman.

7 recordsLinked to original sources
PubMed1977

Jejunal mucosal gamma glutamyl transferase activity in coeliac disease.

In view of data suggesting that deficiency of gamma glutamyl transferase (GGT) may be the primary abnormality in the small-intestinal mucosa of patients with coeliac disease, this enzyme was measured in mucosal biopsies from coeliac patients at different stages of treatment. Activity was only slightly reduced in only one of nine well-treated patients, suggesting that deficiency of this enzyme has no primary role in the aetiology of coeliac disease.

Celiac Disease↗
PubMed1977

The expression enzyme activity of biopsy tissue from the small intestine.

In a study to determine the most suitable method of expressing activity of jejunal mucosal enzymes, the effect of variation of thickness and protein concentration of biopsies was assessed. Despite wide variation of both these factors, we found no advantage in expressing enzyme activity by reference to either surface area or protein content. Expression of activity by reference to weight of biopsy gave the lowest variance for each of the enzymes studied and, since it is also the easiest measurement to make, it would appear to be the preferred means of expressing jejunal mucosal enzyme activity.

Biopsy↗