Biomedical subjects

M J Filiaggi

Publications and source records attributed to M J Filiaggi.

7 recordsLinked to original sources

PubMed2006

Gelled calcium polyphosphate matrices delay antibiotic release.

Introducing a gelling step during antibiotic incorporation has previously been found to delay vancomycin delivery from a calcium polyphosphate matrix intended for local treatment of bone infections. This study examined the general applicability of this approach using cefuroxime, a lower-molecular-weight antibiotic with different charge characteristics compared with those of vancomycin. A calcium polyphosphate/cefuroxime paste was "gelled" in disk form in a humid environment for 5 or 24 hours prior to drying. Antibiotic release in Tris-buffered saline under gentle agitation was monitored over a seven-day period. While non-gelled samples clearly exhibited a burst release, the gelling process significantly retarded early antibiotic release from five- and 24-hour gelled matrices, yielding a constant release rate over the first four days. Cefuroxime incorporation did not appear to alter matrix structure or degradation. Overall, this non-aggressive process effectively trapped cefuroxime and reduced its release rate, suggesting its potential applicability with molecularly diverse therapeutic agents.

Analysis of Variance↗

PubMed2001

Porous calcium polyphosphate scaffolds for bone substitute applications -- in vitro characterization.

Porous structures were formed by gravity sintering calcium polyphosphate (CPP) particles of either 106-150 or 150-250 microm size to form samples with 30-45 vol% porosity with pore sizes in the range of 100 microm (40-140 microm). Tensile strength of the samples assessed by diametral compression testing indicated relatively high values for porous ceramics with a maximum strength of 24.1 MPa for samples made using the finer particles (106-150 microm). X-ray diffraction studies of the sintered samples indicated the formation of beta-CPP from the starting amorphous powders. In vitro aging in 0.1 M tris-buffered solution (pH 7.4) or 0.05 M potassium hydrogen phthalate buffered solution (pH 4.0) at 37 degreesC for periods up to 30d indicated an initial rapid loss of strength and P elution by 1 d followed by a more gradual continuing strength and P loss resulting in strengths at 30d equal to about one-third the initial value. The observed structures, strengths and in vitro degradation characteristics of the porous CPP samples suggested their potential usefulness as bone substitute materials pending subsequent in vivo behaviour assessment.

Bone Substitutes↗

PubMed1999

Evaluating sol-gel ceramic thin films for metal implant applications: III. In vitro aging of sol-gel-derived zirconia films on Ti-6Al-4V.

Sol-gel-derived zirconia films were deposited onto polished Ti-6Al-4V substrates by dip-coating from an alkoxide precursor solution. No change in morphology of the zirconia film was observed after aging at 37 degrees C for 4-12 weeks in pH 4.0 buffer solution or Hanks' balanced salt solution (HBSS), although a precipitate predominantly composed of calcium phosphate was formed on those films aged in HBSS. X-ray diffraction identified the phase of the zirconia film as either cubic or tetragonal, and revealed no degradation to the monoclinic phase after aging. By a substrate straining test, the fracture strain of the coating was revealed to be 1.5%, above the yield strain of the titanium alloy substrate. At this strain level, through-thickness cracks formed in the coating where slip bands emerged from the substrate. Qualitatively, the adhesion of the film was sufficient to prevent gross delamination of the film at high strain levels, although small regions of delamination were caused by compressive buckling of the film. This behavior indicates generally good adhesion. No change in this behavior was observed after aging.

Alloys↗

PubMed1996

Evaluating sol-gel ceramic thin films for metal implant applications. I. Processing and structure of zirconia films on Ti-6AI-4V.

Thin ceramic films or coatings over metallic bone-interfacing implant surfaces have the potential to improve implant performance with respect to implant fixation, wear, or corrosion. In this study, zirconia (ZrO2) thin films formed on Ti-6AI-4V using a polymeric alkoxide-based solgel process were investigated. ZrO2 films of uniform thickness on the order of 100 nm were obtained by dip coating Ti-6AI-4V samples into a zirconium propoxide containing solution using a substrate withdrawal speed ranging from 2 to 8 cm/min and a sol of nominal viscosity approximately 6 cps. These films were essentially free of surface macrodefects but had random submicron "pinholes." X-ray diffraction studies suggested that the films were at least partially crystalline, with some "metastable" cubic and/or tetragonal phases after annealing for 1 h at 500 degrees C. The demonstrated reproducibility of this approach for producing good quality ZrO2 films on Ti-6AI-4V warrants further studies to optimize processing conditions for implant applications.

Alloys↗

PubMed1996

Evaluating sol-gel ceramic thin films for metal implant applications. II. Adhesion and fatigue properties of zirconia films on Ti-6AI-4V.

The degree to which ceramic coatings or thin films applied to bone-interfacing metallic implants can improve the overall performance of these implants with respect to implant fixation, wear, or corrosion relies especially on the response of these films to loading. In this study, the adhesion and fatigue properties of sol-gel zirconia films that could be reproducibly deposited onto polished Ti-6AI-4V substrates was investigated. For zirconia films on the order of 100 nm thick, a shear lag-based strain approach indicated a shear adhesion strength of approximately 275 MPa. Small variations in film thickness and substrate surface preparation had little effect on this adhesion, which was believed to be due to alkoxide molecule interactions with free hydroxyl groups on the substrate surface as well as some limited interfacial diffusion following the 500 degrees C anneal. Subsequent fatigue testing of these films in air using novel tapered rotating beam fatigue samples demonstrated their excellent fatigue characteristics, with films surviving up to 10(7) cycles, the endurance limit of the Ti-6AI-4V (approximately 635 MPa). Overall, the exceptional mechanical properties of this ZrO2/Ti-6AI-4V system along with the inherent advantages of sol-gel processing support continued studies to utilize this technology for implant surface modification.

Alloys↗

PubMed1993

Post-plasma-spraying heat treatment of the HA coating/Ti-6A1-4V implant system.

The metal/ceramic interface that constitutes an important part of the plasma-sprayed HA-coated Ti-6A1-4V system may, in fact, represent the "weak link" in the implant design. A post-plasma-spray heat treatment to enhance chemical bonding at the metal/ceramic interface and, hence, improve the mechanical properties (interface fracture toughness and tensile coating adhesion strength) of the plasma-sprayed implant system does show promise. In preliminary heat treatment studies, however, any improvements realized were lost due to the chemical instability of the coating in a moisture-laden environment, with a concomitant loss in bonding properties. This deterioration in properties appears to be related to environmentally assisted crack growth as influenced by processing conditions. Still, an ability to improve HA/Ti-6A1-4V bonding through enhanced diffusion bonding was demonstrated, warranting further heat treatment studies involving atmosphere control during processing.

Alloys↗

PubMed1991

Characterization of the interface in the plasma-sprayed HA coating/Ti-6Al-4V implant system.

The successful use of plasma-sprayed hydroxyapatite (HA) coatings on Ti-alloy implants for implant-to-bone fixation requires strong adherence of the ceramic coating to the underlying metal substrate. In this study, the metal-ceramic interface was evaluated using mechanical, chemical, and structural characterization methods. Evaluations of an HA-coated Ti-6Al-4V implant system using a modified short bar technique for interfacial fracture toughness determination revealed relatively low fracture toughness values. Additionally, conventional tensile bond strength testing indicated much lower values than previously reported. Using high resolution electron spectroscopic imaging, evidence of chemical bonding was revealed at the plasma-sprayed HA/Ti-6Al-4V interface, though bonding was primarily due to mechanical interlock at the interface. This study illustrates the benefits of, and the need for, a multilevel approach to evaluate and improve these plasma-sprayed ceramic-metal substrate interfaces.

Alloys↗