Biomedical subjects
Publications and source records attributed to M J Flanagan.
Renal medullary carcinoma has recently been described as an aggressive neoplasm affecting young African Americans with sickle cell disease or sickle cell trait. We report the presentation, treatment, and outcome in 3 patients with renal medullary carcinoma along with a description of the unsuccessful treatment attempts. A brief discussion and review of the literature is included.
We report a case of vascular compromise secondary to the reservoir of an inflatable penile prosthesis. The problem masqueraded as deep venous thrombosis in the lower extremity of a patient 3 years after a spinal cord injury.
The tumors in 249 patients presenting initially with stages Ta and T1 bladder cancer were analyzed for tumor progression and recurrence. Only transurethral resection and/or fulguration was used before the first recurrence. Patients who received intravesical chemotherapy after the first tumor recurrence were excluded from an analysis of progression. Progression according to stages Ta and T1, and grades I, II and III was 4, 30, 2, 11 and 45 per cent, respectively. All differences were statistically significant. Progression also correlated with nontumor dysplasia and size. High tumor grade, lamina propria invasion, atypia elsewhere in the bladder, positive urinary cytology, tumor multiplicity and large tumors were associated with shorter intervals free of disease.
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A simple technique for performing a suprapubic cystostomy is presented. The only necessity is a modified male urethral sound.
Urinary cytology is almost as accurate as cystoscopy in appraising the presence or absence of visible tumor. Falsely negative results are virtually limited to low stage, low grade tumors. Urinary cytology often provides information about the neoplastic state of the epithelium not provided by cystoscopic examination. Cytology has become practical and simple to do even as an office procedure. Urinary cytology must be considered an essential part of patient management in bladder cancer surveillance.
Preliminary evidence is presented suggestive of antitumor immunity, cross reactive with allogeneic extracts from tumors of the same type, and serum-blocking factor(s), which appear to be specific to autologous tumor only, in patients with prostatic cancer employing the method of leukocyte adherence inhibition.
Local vesical absorption of organic compounds may play a role in the pathogenesis of bladder cancer. An associated increased absorption of tryptophan in patients with bladder cancer has been demonstrated.
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