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Biomedical subjects

M J García Miguel

Publications and source records attributed to M J García Miguel.

10 recordsLinked to original sources
PubMed2003

[Incidence and clinical characteristics of Kawasaki's disease].

OBJECTIVE: The aim of this study was to analyze the incidence and clinical spectrum of Kawasaki's disease in children attended in our hospital. PATIENTS AND METHODS: Retrospective review of all children with Kawasaki's disease evaluated in the Department of Infectious Diseases of Hospital La Paz (Madrid, Spain) from January 1999 to June 2002. Information included clinical manifestations, age, sex, seasonal occurrence, treatment, development of cardiovascular abnormalities, and incidence rate. RESULTS: Forty-five patients with Kawasaki's disease were analyzed during the study period. Age ranged between 4 months and 13 years. Thirty-seven children were aged 5 years old or less and 15 children were younger than 2 years. The most common symptom was fever in 98 % of the patients. Five patients developed coronary aneurysms. Of these, four were aged less than 2 years and three were treated after the first week of onset of fever. The annual incidence rate in our health area was estimated at 15.1 cases per 100,000 children aged 5 years or less. CONCLUSIONS: The annual incidence rate for Kawasaki's disease in our area was similar to that in Europe and the United States. Coronary aneurysms were more common in children aged less than 2 years and in patients who received treatment after 1 week of the onset of fever.

Adolescent↗
PubMed2002

[Acute mastoiditis: an increasing entity].

BACKGROUND: Mastoiditis used to be the most common complication of acute otitis media. However, once antibiotics became widely available, it was rarely reported. Recently, this complication has become more frequent. OBJECTIVES: To determine the frequency of acute mastoiditis in our center in the last few years and to analyze the clinical and bacteriologic characteristics of the patients with this diagnosis. METHODS: Retrospective analysis of all patients admitted to our hospital with a diagnosis of acute mastoiditis from 1994-2001. RESULTS: One hundred patients were diagnosed with acute mastoiditis during the study period. The mean age was 2 years and 10 months (range: 2 months-13 years) and the median age was 15 months. The mean number of episodes was 12.5 cases of acute mastoiditis per year, but 52 % of the cases occurred from 1999-2001. Culture of middle ear effusions was performed in 47 patients, revealing Streptococcus pneumoniae in 17, Haemophilus influenzae in 3, and other pathogens in 10 children. Cultures were sterile in 17 patients. Three children did not respond to medical therapy and required mastoidectomy. CONCLUSIONS: In the last few years, the incidence of acute mastoiditis in our population has increased considerably. This complication is more common in children aged less than 2 years.

Acute Disease↗
PubMed1992

[Long-term follow-up study of 35 children with ADS treated with zidovudine (AZT)].

Thirty-five children diagnosed of AIDS were studied in order to evaluate toxicity and efficacy of oral Zidovudine treatment (AZT), as well as to analyze the clinical, biochemical, immunological and virological evolution of HIV infection throughout the treatment. Patients (19 males and 16 females) were studied from April 1988 to May 1990 with a mean follow-up time of 13.5 months (SD = 6.7 months). The mean age of the group was 4.68 years. The means of acquisition of this disease was 71.45 vertical and 28.6% via hemo-derivatives. Tolerance has been good with the main toxicity being hematological (28.5% anemia and/or neutropenia), 23% of which required blood supplements. The presence of neurological involvement and thrombopenia were observed in the incidence of greater toxicity. No influence on weight during AXT treatment was observed and hepatosplenomegalia and adenopathies were not modified. Bacterial and opportunistic infections were observed in 97.1% and 20% of patients, respectively. Neurological evolution was irregular and the improvement observed in some patients was mild and transitory. Three patients died during the follow-up from intercurrent infectious process. A progressive increase in MCV and a tendency towards leucopenia and lymphopenia (mainly in hemo-derivative infected patients) was observed. Neither significant immunological nor virological changes were observed during the treatment (except the tendency to diminish basal hypergammaglobulinemia). The results of this study were compared to other pediatric series treated with AZT.

Acquired Immunodeficiency Syndrome↗
PubMed1985

[Boutonneuse fever in children].

Due to an increase in the number of cases of spotted fever, a prospective study was undertaken in 31 children affected by the disease, including clinical, laboratory and microbiological data from may to october of 1983. The most frequent symptoms found were: fever 100%, "tache noire" 87%, and a maculopapular rash 81%. The Weil-Felix reaction was positive in 65% of them and indirect immunofluorescence was positive in 81%, confirming the sensitivity and specificity of this serologic procedure. The 27 children who received specific treatment, 26 with tetracycline and one with chloramphenicol, differed considerably in a lesser duration of their symptoms, in comparison with the group of children without treatment.

Boutonneuse Fever↗
PubMed1983

[3 patients with maple syrup urine disease].

Clinical manifestations, biochemistry and treatment of three patients with the inherited alteration of the so called maple syrup urine disease are presented. Diagnosis was based upon both detection of high concentrations of leucine, isoleucine, valine and their corresponding alpha-ketoacids in plasma and urine, and existence of a peculiar odor as well as an intense, progressive, neurological alteration. Considering the early onset of clinical symptoms, low protein tolerance and very reduced rate of leucine decarboxylation in cultured fibroblasts, the three patients exhibited grade I, classical type of this disease. None of them responded favorably to suprapharmacological doses of thiamine. Treatment of the patients is discussed and compared with that recommended in the literature.

Amino Acids, Branched-Chain↗
PubMed1982

[Eosinophilic fasciitis].

A three year old is described with clinical findings of oedema and induration of skin in the right leg, eosinophilia, hypergammaglobulinemia, and pathological lesions of eosinophilic fasciitis in the deep muscle's fascia. 94 cases published in the literature are reviewed and clinico-biochemical pathological findings and outcome of this syndrome discussed. In general this entity has a good prognosis with steroid therapy. Authors emphasise the rarity of the disease in children, and the early onset in their patient.

Adrenal Cortex Hormones↗
PubMed1981

[Campylobacter gastroenteritis in infants (author's transl)].

Fourteen children with Campylobacter gastroenteritis have been observed during a 4-month period; age ranged from one to 24 months. Clinical and epidemiological aspects and therapy of our patients are compared with previous references. Authors intend to draw attention to this kind of infection, few cases of which have been notified up to 1977, but from this date on, number of published cases is increasing.

Anti-Bacterial Agents↗