The treatment of endotoxin shock by beta adrenergic blockade.
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Animals↗
Biomedical subjects
M J Gerber
Publications and source records attributed to M J Gerber.
Induction of penicillinase with inorganic phosphate.
Phosphate stimulates penicillinase formation in Bacillus cereus 569. The rate of penicillinase synthesis in the presence of 0.3 m phosphate, pH 7.0, is approximately 10-fold greater than that for uninduced cells, while the rate of synthesis in the presence of 0.3 m phosphate and 1 unit/ml of penicillin is approximately fourfold greater than in the presence of penicillin alone. When phosphate-induced cells are transferred to low phosphate medium, the rate of penicillinase synthesis rapidly reverts to that of uninduced cells. Furthermore, the phosphate-induced synthesis of the enzyme is inhibited by either chloramphenicol or actinomycin D. These antibiotics are known to inhibit protein synthesis and deoxyribonucleic acid-dependent ribonucleic acid (RNA) synthesis, respectively. Thus, phosphate appears to induce the synthesis of a species of RNA that is required for the synthesis of penicillinase in B. cereus 569. The penicillin-dependent induction lag for penicillinase was compared in high and low phosphate media. It was found that, at 37 C, the penicillin-dependent lag is approximately 3 min in the presence of 0.3 m phosphate and approximately 6 min in low phosphate medium.
Bacillus cereus↗
Measurement of background urban nitrogen dioxide pollution levels with passive samplers in Montpellier, France.
Background nitrogen dioxide (NO2) pollution levels in Montpellier were measured in the context of an assessment operation carried out by the local monitoring network (AMPADI-LR), using Palmes passive samplers. The equipment was validated by continuous measurement with automatic chemiluminescence analyzers. Measurements from representative background pollution sites and the ensuing cartographic representation provide information about local pollution data, a description of seasonal evolution and an assessment of the influence of various sources. The study may be used to define parameters for establishing an exposure index, taking into account roads with heavy traffic, which affects the distribution of NO2 over Montpellier, and meteorological factors. This is a pilot study which will subsequently be used for a more precise assessment measuring the personal exposure of inhabitants, for the purposes of a study on effects on health.
Analysis of Variance↗