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Biomedical subjects

M J Gore

Publications and source records attributed to M J Gore.

At least 19 recordsLinked to original sources
PubMed1999

Reducing variation in care.

What care a patient receives reflects not only best practices and available technology but also geography, provider experience and patient preference. Spurred on by payers and a growing body of evidence-based methodology, providers are seeking to make patient care more consistently reflect best practices.

Benchmarking↗
PubMed1998

Identifying and meeting community healthcare needs--from the beginning.

Prerequisite to implementing effective community improvement projects are a statement of the group's purpose, decisions on which dimensions of health status to measure--and a way to move from assessment to action. Learn what four components must be in place before starting the improvement effort.

Community Health Planning↗
PubMed1991

Expression of nicotinic acetylcholine receptor subtypes in brain and retina.

Neuronal nicotinic acetylcholine receptors (AChRs) are composed of two types of subunits: ACh-binding (termed alpha 2, alpha 3, alpha 4 ...) and structural (termed beta 2, beta 3, beta 4 ...). AChR subtypes composed of combinations of subunits of these two types encoded by several related genes are expressed in different parts of the nervous system, where they presumably serve different functional roles. Here we identify the ACh-binding subunit of the most prominent chicken brain AChR subtype by N-terminal amino acid sequence and show that it corresponds to the alpha 4 gene. Previously we identified the structural subunit for this AChR subtype from chicken brain as beta 2 by N-terminal amino acid sequence. Thus, this identifies both genes which encode subunits of the major nicotinic AChR subtype in avian brains. By immunoprecipitation, immunohistochemistry, and northern blot analysis we show that alpha 3 (or a very closely related sequence) is expressed at low levels in the brain and relatively high levels in the retina, while alpha 4 is expressed at high levels in the brain and lower levels in the retina. This differential expression indicates that alpha 3-containing 'ganglionic-type' AChRs may be an important AChR subtype in avian retina.

Amino Acid Sequence↗