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Biomedical subjects

M J Grimes

Publications and source records attributed to M J Grimes.

8 recordsLinked to original sources
PubMed1993

TB control in the hospital environment.

Tuberculosis is again on the rise in the United States. Several outbreaks of TB in hospitals have heightened interest in the development and use of mechanisms that prevent the spread of this airborne pathogen. Controlling the spread of TB to hospital patients, workers, and others can be accomplished through various administrative engineering and design controls, and infection control programs, as recommended by the Centers for Disease Control and Prevention (CDC). The hazard of TB is real, but workers, patients, and visitors can be protected by implementing programs that guard against the diseases spread in the hospital environment.

Centers for Disease Control and Prevention, U.S.↗
PubMed1987

Health advocacy for young, low-income, inner-city women.

The Urban Women's Health Advocacy Training Project was a university-based demonstration program designed to collect data on the health status of urban women and to test nursing interventions for training community health advocates. Thirty Hispanic and black trainees between 17 and 21 years of age were selected to participate in an eight-week, 20-h/w program emphasizing women's health education, health advocacy skills, and career awareness. This project has many implications for nursing practice with young, inner-city women. Enhancing the self-care and advocacy skills of these women maximizes their potential for use of available health services and their ability to influence the expansion of the services required to meet their own and their families' health care needs. Problems in funding and conducting such demonstration projects are discussed.

Adolescent↗
PubMed1986

Human overdose with the veterinary tranquilizer xylazine.

Three patients self-injected the veterinary tranquilizing agent xylazine (Rompun). The first patient developed mild bradycardia and hypotension, miosis, and a feeling of disorientation. The other two patients became apneic and required intubation and mechanical ventilation. Initial mild hypertension followed by mild hypotension and a mildly elevated blood glucose was seen in the second patient, whereas both the second and third patients developed mild bradycardia. Xylazine has structural similarity to the phenothiazines and pharmacological activity similar to clonidine. With increasing veterinary use, the availability and potential for human exposures may also increase.

Adult↗
PubMed1985

Ultrastructural correlates of transmitter release in presynaptic areas of lamprey reticulospinal axons.

The ultrastructure of presynaptic areas of lamprey reticulospinal axons was studied before, during, and after periods of elevated transmitter release produced either by repetitive action potential activity or depolarization by elevated extracellular potassium. Controls for possible effects of these procedures per se were done by replacing extracellular Ca with Mg to block transmitter release. In some experiments the time course of ultrastructural changes during K depolarization and subsequent recovery were studied by fixing tissue samples at various times. Transmitter release produced by action potential activity (20/sec for 15 min) in the presence of extracellular Ca significantly and reversibly decreased the number of synaptic vesicles, the area occupied by the vesicles, and the density of synaptic vesicles. An unexpected finding was a reversible decrease in the length of the differentiated membrane during periods of increased transmitter release. Transmitter release significantly and reversibly increased the number of coated vesicles, expanded the presynaptic membrane, and increased the number of pleomorphic vesicles. K depolarization (50 mM K for 15 min) produced identical, reversible effects, except that the expansion of the presynaptic membrane, although significant, was relatively small and there was no change in the number of pleomorphic vesicles. Raising the temperature of the saline from 2 degrees C (K depolarization experiments) or 7 degrees C (action potential experiments) to 20 degrees C did not change the results qualitatively but did produce somewhat larger effects during stimulation and appeared to increase the speed of recovery. Action potential activity or K depolarization in control experiments with the Ca in the saline replaced by Mg had little or no effect on synaptic ultrastructure. Synaptic vesicles in lamprey reticulospinal axons never contacted the axonal membrane anywhere other than at the differentiated membrane. During periods of elevated transmitter release, although the absolute number of vesicles in contact with the differentiated membrane decreased, the percentage of total vesicles in contact with the differentiated membrane increased dramatically. This suggests that the differentiated membrane is the site of vesicle release and there is an active process of vesicle movement to this membrane. In the course of this work it was observed that presynaptic areas closer than approximately 2 mm to the site of axonal transection, regardless of the composition of the saline or the experimental conditions, showed ultrastructural changes typical of increased transmitter release.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗