Experimental human exposure to high concentrations of carbon monoxide.
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Biomedical subjects
Publications and source records attributed to M J Hosko.
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Inhalation of dichloromethane vapor in concentrations of 500 to 1000 parts per million for 1 to 2 hours promptly initiated the formation of significant quantities of carbon monoxide in human subjects. The evidence suggests that carbon monoxide may be a metabolite of dichloromethane and, that exposure to concentrations of dichloromethane below the industrial threshold limit values may result in the formation of carbon monoxide in amounts that exceed the allowable limits.
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A variable mechanical occluder has been designed which, by means of a micrometer, permits graded stenosis of an artery in precise, reproducible increments. The design also allows transient, complete occlusion of the artery to establish zero flow without alteration of the level of stenosis established prior to the zeroing procedure. The device has been used to partially block the reactive hyperemic response following coronary and femoral artery occlusion, but is readily adaptable to vessels of other size by means of an interchangeable occluder subassembly.
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