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Biomedical subjects

M J Jaeger

Publications and source records attributed to M J Jaeger.

At least 37 records · Page 2Linked to original sources
PubMed1982

Respiratory resistance from 1 to 46 ATA measured with the interrupter technique.

Measurements of respiratory resistance by an interrupter technique were made in six subjects during a Navy saturation dive to 457 m. Repeated measurements were made at five depths with complete pulmonary function testing after the dive. Increase in resistance was about linear with gas density (rho). Three smokers exhibited a significantly steeper slope of the respiratory resistance versus rho relationship than three nonsmokers. The disparity in resistance among the divers became considerable only at great pressure. Likewise, the predictions of two contradictory fluid dynamic theories agreed fairly well with our data and with each other over the densities explored and disagreed greatly with our data only at higher pressures.

Adult↗
PubMed1981

Flow partitioning in symmetric cascades of branches.

We have found markedly nonuniform partitioning of flow in idealized models of physiological cascades of branches. Liquids having viscosities of 0.8-7.0 cP were used to investigate this effect systematically in a regime characterizing a limited range of pulmonary flows, comprising inlet flow rates of 500-3,000 ml/min and branch diameters of 1.0 cm ID. Factors that affect the nonuniformity of inspiratory flow include inlet velocity profile and flow rate, cascade aspect (L/D) ratio, exit pressure distribution, and, to a lesser extent, kinematic viscosity (mu/rho). More qualitative observations using sinusoidally oscillating airflow revealed inspiratory and expiratory flow patterns to be quite dissimilar, emphasizing the inadequacy of a resistance model of flow partitioning based on Kirchhoff's law. These results might suggest, in part, why regional ventilation in man is flow or frequency dependent and how bronchial smooth muscle could fine tune regional ventilation.

Airway Resistance↗
PubMed1981

Pulmonary diffusing capacity and physical working capacity in swimmers and non-swimmers during growth.

We measured physical working capacity at a heart rate of 170 bpm (PWC170) and diffusing capacity for carbon monoxide (DLCO) in two groups of children ranging in age from 9 to 17 years. One group was formed of highly trained competitive swimmers and the other of age, sex and size matched untrained counterparts. Bicycle ergometry was used to establish PWC170. The DLCO was measured at rest (DLCO rest) and while pedalling at 170 bpm (DLCO ex). The PWC 170, DLCO rest and DLCO ex were significantly higher in swimmers than in non-swimmers. Repeated measurements in the same subjects show that individual increases in DLCO rest and DLCO ex were result of both growth and training.

Adolescent↗
PubMed1980

Non-invasive lung function tests in rats with progressive papain-induced emphysema.

Non-invasive plethysmographic methods for measurement of thoracic gas volume (TGV), airway resistance (Raw) and phase difference (PD) between flow rate at the nose and mean alveolar pressure were adapted for use in anesthetized rats. Thirty-six male Sprague-Dawley rats (200-250 g), were treated in groups of six by a single transoral, intratracheal instillation of 2 mg . kg-1 or 4 mg . kg-1 of papain in saline, or left untreated as controls. Measurements of TGV, Raw, and PD were made before treatment and at 4-day intervals after treatment for 8 or 16 days. TGV increased 65 percent by the fourth day and showed no change beyond the eighth day. Raw (0.4 +/- 0.04 cm H20 . ml-1 . sec) was not different from that of the controls. PD did not change significantly from the pretreatment value (4.7 +/0 0.41 degrees). The TGV, Raw, and PD responses were similar in the 2 mg . kg-1 and 4 mg . kg-1 papain treated rats. The TGV results suggest that the destructive effects of papain on the lungs are complete by the eighth day. The Raw results indicate that the airways are unaffected. The PD data are consistent with theoretical modeling studies for uneven distribution of compliances but neglible inequality of peripheral resistances.

Airway Resistance↗
PubMed1980

Effect of positive end-expiratory pressure on dynamic respiratory compliance in neonates.

A simplified method of determining dynamic respiratory compliance (C dyn) in the newborn is described. Studies were performed during mechanical ventilation on 24 infants with respiratory distress syndrome (RDS) and 6 infants without RDS. Cdyn was evaluated at pressure settinghs of 20/0, 25/5 and 30/10 cm H2O. Significant decreases (p < 0.05) in Cdyn were noted with each increase in end-expiratory pressure setting. The values for Cdyn in RDS patients obtained by this method closely approximated previously published data for lung compliance in babies with RDS. This simple and reproducible method may be useful in following the course of illness in infants with RDS.

Forced Expiratory Flow Rates↗
PubMed1976

Uneven ventilation in smokers.

A body plethysmographic technique designed to detect small degrees of uneven ventilation in the lungs is presented. The technique is based on the same theoretical model as the frequency dependence of compliance. It has the advantage of requiring little time, no cooperation by the subject and no computation. Signs of uneven ventilation were found in 3 of the 42 normal controls, in 6 of 51 light smokers and in 66 of 103 heavy smokers. The data are compared with measurements of closing volume, of the slope of phase III of the single breath nitrogen washout and of maximal mid-expiratory flow rate.

Adult↗
PubMedDate not supplied

Granular cell tumor of the orbit and ocular adnexae.

Although granular cell tumor (GCT) has been a distinct pathological entity since 1926, confusion and controversy have long existed regarding the nature and histogenesis of the tumor. Twenty-five cases of granular cell tumor involving the orbit and ocular adnexae previously reported in the ophthalmic literature, are reviewed and six additional cases are reported. The histopathological and immunohistochemical characteristics of granular cell tumors in this uncommon location are discussed and their probable origin from Schwann cells is also considered.

Eyelid Neoplasms↗
PubMedDate not supplied

Plasma delta-9-tetrahydrocannabinol in pregnant sheep and fetus after inhalation of smoke from a marijuana cigarette.

Seven pregnant ewes were prepared with open-ended tracheal T tubes and with catheters in maternal femoral artery and in central circulation of fetus. Several days postoperatively, at 129-132 days gestation, ewes inhaled smoke from one marijuana cigarette containing 3.19% delta-9-tetrahydrocannabinol (delta-9-THC). Smoke was produced continuously in a hand-held chamber and delivered to the protruding arm of the tracheal tube. Samples of maternal and fetal blood were taken during the 8-10 minute smoking period and at intervals up to 24 hours. Delta-9-THC was detected in maternal plasma at 3 minutes and peaked at 10 minutes. Fetal plasma delta-9-THC reached detectable levels in 5 animals by 10 minutes. Maximum mean level was reached at 90 minutes and remained nearly constant until the fourth hour. Fetal delta-9-THC levels remained lower than maternal levels at all times. The terminal half-life of delta-9-THC in fetal and maternal plasma exceeded 10 hours.

Animals↗