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Biomedical subjects

M J Jeffrey

Publications and source records attributed to M J Jeffrey.

12 recordsLinked to original sources
PubMed2000

The importance of skip lesions in temporal arteritis.

AIM: To determine the frequency of skip lesions in an unselected series of temporal artery biopsies and compare the results with other series. METHODS: The study was a retrospective review of 102 consecutive temporal artery biopsies taken in a five year period (1992-1997) in one large hospital. RESULTS: 35 cases (34.3%) showed evidence of active cranial vasculitis with pathological evidence of inflammation of the intima or media, with or without giant cells. Three of these cases (8.5%) showed apparent skip lesions: normal intima, media, and adventitia in one segment while in other segments there was clear evidence of active vasculitis. Immunocytochemical stains for leucocyte common antigen (LCA) and CD15 were helpful in identifying the absence of intimal or medial inflammatory cell infiltrates within skip lesions. Skip lesions have been described in up to 28.3% of cases in some series, while others have not found evidence of skip lesions or have identified them in a much smaller percentage of cases. CONCLUSIONS: In this series skip lesions were relatively rare, accounting for 8.5% of cases of active vasculitis. The degree of inflammation in temporal arteritis is discontinuous. Immunostaining for inflammatory cells, for example LCA and CD15, may be helpful in identifying the presence of an inflammatory cell infiltrate in skip lesion segments of the temporal artery.

Biopsy↗
PubMed1996

Availability for poults of phosphorus from meat and bone meals of different particle sizes.

Two experiments were conducted to compare the dietary availability of P from meat and bone meal (MBM) with that of P from dicalcium phosphate (DP) for poults. Two batches of the same MBM were tested. The batches differed in fineness of grind; one was passed through a 10-mesh screen (openings of 2.03 mm) (MBM1O) and the other through a 12-mesh screen (openings of 1.91 mm) (MBM12). In Experiments 1 and 2, the low-P basal diets contained, by analysis, 0.54% P (0.2% nonphytate P) and 0.64% P (0.3% nonphytate P), respectively. Each batch of MBM and DP were included in isocaloric, equinitrogenous diets to obtain increments of 0.1, 0.2, 0.3, and 0.4% P added to the basal diet. Three pens, each containing seven poults, were assigned to each of the 13 dietary treatments. Poults were fed the diets from 5 to 11 and 6 to 13 d of age in Experiments 1 and 2, respectively. Regression analyses of the data showed that increases in BW and tibia ash were linearly related (P </= 0.01) to percentage dietary P and to quantity of P consumed. Common intercept multiple linear regression was used to derive relative availabilities (RA) with DP assigned a value of 100. On the basis of BW gains, RA of MBM1O and MBM12 ranged from 99.1 to 105.5, depending on the independent variable and the experiment. Similarly, on the basis of tibia ash, RA ranged from 97.3 to 104.8. None of the RA differed (P > 0.05) from 100. Thus, the RA of P from MBM tested were equal to that of P from DP, and particle size of the MBM did not affect RA of P.

Animals↗
PubMed1995

Effects of early immune stress and changes in dietary metabolizable energy on the development of newly hatched turkeys. 2. Selected characteristics of immune function.

Two 21-d experiments were conducted to document the effects of an early immunologic stress and changes in dietary ME(n) on selected characteristics of immune function of newly hatched turkeys. Eight treatments were included in each experiment. Treatments were the result of complete factorial arrangements of two types of injection and four isonitrogenous diets. Turkeys in both experiments were injected i.p. with .5, .5, and .2 mL of saline (SAL) or .5, .5, and .2 mL of a solution of Escherichia coli lipopolysaccharide (LPS) (100 micrograms LPS/mL SAL) at 1, 3, and 5 d of age, respectively. In Experiment 1, two diets were formulated to contain 2,800 kcal ME(n)/kg. One was a corn-soybean meal based diet (CSBM) and the other contained 8% Solkafloc (SKF). A third diet (3,100 kcal ME(n)/kg) was formulated by substituting 8% sucrose (SUC) for the 8% SKF. The fourth diet (HE) included in Experiment 1 was formulated to contain 3,700 kcal ME(n)/kg. The CSBM and SUC diets and two additional diets were tested in Experiment 2. The latter were the CSBM diet containing 74.5 mg ibuprofen/kg (IBU) and a corn-soybean meal diet formulated to contain 3,100 kcal ME(n)/kg (CS31). Concentrations of plasma IgG and jejunal IgG and IgA were not affected by injection or diet. Age-related changes in Ig concentrations were consistently observed in Experiments 1 and 2. Injection with LPS reduced the number or responses of blood leukocytes to mitogens at 8 d of age (P < .01), as compared with samples from turkeys injected with SAL. Leukocytes in whole blood samples from turkeys fed the HE diet responded less to LPS stimulation than those fed the SUC diet (P < .01). Injection with LPS did not markedly affect the characteristics of immune function studied, and feeding a diet with 3,100 kcal ME(n)/kg and 28.5% crude protein did not measurably affect the characteristics of immune function of young turkeys.

Animal Feed↗
PubMed1994

Influence of amino acid supplementation of low-protein diets and metabolizable energy feeding sequence on performance and carcass composition of toms.

An experiment was conducted to determine the influence of essential amino acid (EAA) supplementation of low-protein diets and of MEn feeding sequence on performance and selected carcass characteristics of turkey toms. Feeding diets containing 93 or 100% of the protein and 100% of the EAA concentrations recommended by NRC (1984) or a diet containing 93 and 107% of the recommended protein and EAA concentrations, respectively, had no effect on BW or feed efficiency of toms at 104 or 117 d of age. Dietary protein-EAA concentrations also had no effect on carcass and breast meat yields or proximate composition of carcasses at 105, 112, or 118 d of age, irrespective of MEn feeding sequence. Feeding diets supplying 108% of the MEn concentrations (MH) listed by NRC from 41 to 104 d improved BW (P < .02) and feed efficiency (P < .01) as compared with feeding 102% (M) of the MEn listed by NRC, but only the improvement in feed efficiency was evident at 117 d. Feeding diets supplying 108% MEn from 41 to 104 d, followed by the 102% MEn diet from 104 to 117 d (MHM), resulted in the same 117-d BW and feed efficiency as feeding the MH MEn sequence from 41 to 117 d. Metabolizable energy feeding sequence had no consistent effect on carcass or breast meat yields. Feeding the MHM sequence decreased (P < .05) fat pad and carcass fat of toms processed at 105, 112, and 118 d, compared with the MH feeding sequence. However, fat pad and carcass fat of toms fed the MHM MEn sequence generally exceeded those of toms fed M MEn diets from 1 d to time of processing.

Amino Acids, Essential↗
PubMed1989

Enhanced growth of tumour cells in healing colonic anastomoses and laparotomy wounds.

In the past, it has been noted that experimental tumour cells inoculated into the peritoneal cavity or into the lumen of the bowel will grow at a recently formed colonic anastomosis. However, it has previously been unclear whether the healing process enhances tumour growth or whether the presence of a suture line merely allows the tumour cells to gain access to the tissues. In the present study, using the hooded Lister rat, we have confirmed these findings by showing that growth of the syngeneic MC28 sarcoma and OES5 breast carcinoma occurs preferentially at colonic anastomoses and laparotomy wounds after intraperitoneal injection, and at colonic anastomoses after intraluminal injection. In previous studies using the MC28 sarcoma and the OES5 breast carcinoma injected by the intracardiac route (so that tumour cells reach normal and healing tissues in approximately equal numbers) we have shown that tumour growth is enhanced in healing wounds but not in the surrounding normal tissues when cells reach a healing colonic anastomosis or laparotomy wound within 2 h of its formation. Furthermore, by studying the distribution of radiolabelled tumour cells after intracardiac injection, we have calculated that the probability of a tumour cell leading to a deposit in a healing anastomosis or laparotomy wound is increased 1,000 fold compared to normal tissue. No previous studies have combined the data for intracardiac, intraluminal and intraperitoneal injection of tumour cells using the same animal model. We conclude that the same phenomenon of tumour growth enhancement in colonic anastomoses and laparotomy wounds reported after intracardiac injection of tumour cells may well be enhancing tumour growth after intraperitoneal and intraluminal injection.(ABSTRACT TRUNCATED AT 250 WORDS)

Anastomosis, Surgical↗
PubMed1989

Adrenoleukodystrophy: heterogeneity in two brothers.

A man with hypoadrenalism died from a rapidly progressive pseudobulbar palsy, due to adult onset adrenoleukodystrophy. This diagnosis suggested that his brother, with a longstanding spastic paraparesis, suffered from adrenomyeloneuropathy. Both cases were confirmed biochemically. The heterogeneity of expression of this x-linked disorder is described, with the consequent difficulty in diagnosis and nomenclature.

Adrenoleukodystrophy↗
PubMed1988

Preferential growth of bloodborne cancer cells in colonic anastomoses.

Intracardiac injection, in hooded Lister rats, of syngeneic MC28 sarcoma cells never induced tumour growth in normal bowel. Tumour growth occurred at the site of a colonic anastomosis if surgery preceded tumour injection but not if it followed tumour injection, even by as little as 1 h. Maximum enhancement of tumour growth occurred when the healing process had progressed between 2 and 8 days, with a peak at 5 to 7 days. The enhancing effect was largely over by the time the healing had progressed 14 days. The syngeneic OES5 breast carcinoma also grew at colonic anastomoses when surgery preceded tumour injection by 5 days, but not in normal colon. The MC28 sarcoma also grew at ileal anastomoses but not in the normal ileum after intracardiac injection. By injecting radiolabelled sarcoma cells, an estimate of the probability of a single bloodborne tumour cell lodging at a colonic anastomosis and leading to a tumour deposit was calculated to be of the order of 1:43 whereas the probability of the cell lodging in normal colon and causing a deposit is less than 1:4 x 10(4).

Anastomosis, Surgical↗
PubMed1978

Community mental health services in rural areas: some practical issues.

Several critical issues involved in successfully initiating and maintaining a community mental health center program in a rural setting are discussed. These include the necessity of accurately assessing the existing social, cultural, and political system, and of fitting the mental health center program into these systems as smoothly as possible; the special problems faced in maintaining confidentiality; and the importance of recognizing and dealing with the front-line pressures on professional staff that are peculiar to the rural setting. Advantages as well as disadvantages of working in a rural program are considered.

Attitude of Health Personnel↗