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Biomedical subjects

M J Jesse

Publications and source records attributed to M J Jesse.

At least 19 recordsLinked to original sources

Genetic variance of weight and length in infant twins.

A population-based cohort of 166 twin pairs (67 monozygotic and 99 dizygotic) born at the Jackson Memorial Hospital/University of Miami Medical Center, from July 1, 1976 to December 31, 1980 was identified. Body weight and length were measured at 14 days and at one, three, six, nine, and 12 months of age. Statistically significant genetic variance was found for both body weight and length at each data point. Heritability for body weight increased from 0.28 at 14 days to 0.64 at one year. Corresponding values for body length were 0.16 and 0.48.

Body Height

Genetic variance of blood pressure levels in infant twins.

A cohort of 166 twin pairs (67 monozygotic and 99 dizygotic) born at the Jackson Memorial Hospital/University of Miami Medical Center between July 1, 1976 and December 31, 1980, was followed from birth to one year of age in order to estimate the genetic variance of blood pressure during the first year of life. The sex-adjusted summary estimate of heritability for systolic blood pressure during all of infancy was 0.22 (p less than 0.001), but statistically significant genetic variance was not found for diastolic blood pressure. When using blood pressures from six to 12 months of age, adjusted for infant sex, heritability was estimated as 0.33 (p less than 0.001) for systolic blood pressure and 0.24 (p = 0.04) for diastolic blood pressure; adjustment for body weight reduced these estimates to 0.27 (p less than 0.001) and 0.17 (p = 0.13), respectively.

Blood Pressure

Retirement and coronary mortality.

Information on several variables, including occupational history and various coronary risk factors, was collected from the wives of 568 married men who died of coronary heart-disease (CHD) and an equal number of matched control subjects. The crude matched-pair relative risk of fatal CHD among men who retired compared with non-retirees was 2.9 (95% confidence limits from 1.9 to 4.9). After adjustment for age and history of hospitalisation for myocardial infarction by means of a paired multiple-logistic regression analysis the relative risk was reduced to 1.8 (range 1.0 to 3.3). These data suggest that retirement and subsequent coronary mortality may be linked.

Adult

Effect of Position on Blood Pressure in Infants.

In order to estimate the effect of position on blood pressure measurements during the first year of life, pressures were recorded for 71 infants at one, three, six and twelve months of age in both the propped and lying positions. The position of the infant appeared to have little effect on mean values or upon the correlation of measurements over time. These results favor the use of a position for blood pressure measurement during infancy which places primary importance upon the comfort of the child.

Blood Pressure

A longitudinal evaluation of blood pressure in children.

Blood pressure levels obtained on two occasions, one year apart, were evaluated among 212 children. An overall correlation of .65 was obtained for systolic pressure and .43 for diastolic pressure. The results suggest that adult levels of correlation are not reached in childhood and that screening programs must consider the relative lability of children's measurements in establishing referral criteria.

Adolescent

Cigarette consumption and deaths from coronary heart-disease.

There is a positive association between cigarette smoking and coronary heart-disease (C.H.D.). In non-fatal myocardial infarction a dose-response relation persists even after the effects of additional variables have been controlled for. The relation between cigarette consumption and deaths from C.H.D. was investigated in a matched-pair case/control study. The overall simple matched-pair risk ratio (R.R.) between current smokers and non-smokers was 1.9 (95% confidence limits 1.5-2.4). For smokers of fewer than 20 cigarettes per day, the R.R. was 1.2; at a level of 21-40 cigarettes per day, the R.R. was 2.3; and for smokers of 41+ cigarettes per day, the R.R. was 4.0. A similar relation was found after adjustment for additional variables. These results suggest that the heaviest smokers could halve their risk of death from C.H.D. by reducing their tobacco consumption to an intermediate level; and that benefit of a similar order would be experienced by smokers of 21-40 cigarettes per day who cut down to less than one pack (20 cigarettes) daily.

Adult

Lung mechanics in congenital heart disease with increased and decreased pulmonary blood flow.

Respiratory rate, tidal volume, dynamic lung compliance, functional residual capacity, and pulmonary resistance were measured withim 24 hours of cardiac catheterization in 25 infants, 12 of whom had increased pulmonary blood flow and 13 of whom had decreased PBF. There were no differences in the two groups of patients with respect to VT and FRC. Respiratory rate and pulmonary resistance were higher in infants with increased PBF. Lung compliance was significantly lower in infants with increased PBF (4.9 ml/cm H2O) than in those with decreased PBF (8.9 ml/cm H2O) (P less than 0.01). The decrease in CL in infants with increased PBF significantly correlated with mean pulmonary artery pressure (r = 0.798). No correaltion was found between CL and left atrial pressure or magnitude of the left-to-right shunt. Compliance was normal in patients with increased PBF and normal PAP, suggesting that PAP and not PBF is the primary factor that affects CL in patients with intracardiac left-to-right shunts.

Airway Resistance