Medullary sponge kidney and congenital hemihypertrophy: case report and literature review.
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Adult↗
Biomedical subjects
M J Kaempf
Publications and source records attributed to M J Kaempf.
New concepts on formation of Brunn's nests and cysts in urinary tract mucosa.
To the present time, Brunn's nests have been conceived as being the result of pinching off of epithelial nests from urothelial buds. Mucosal cysts were considered to originate from Brunn's nests. In the present study, it was observed that under the influence of a strong stimulus of repair, the urothelial cells in the proximity of the focus of repair undergo numerous mitoses. The underlying connective tissue becomes loose, isolated cells of the lining urothelium "drop off" into the lamina propria in which they migrate as in a culture medium. There they multiply and form nests of cells at a distance from the lining urothelium. These migrating cells frequently have an early tendency to become arranged into cysts. Thus, during this process of repair urothelial cells behave temporarily as malignant cells.
Animals↗
Prostatic cancer revisited.
Thirty patients with prostatic carcinoma treated for varying lengths of time by radiation or endocrine therapy alone and in combination underwent staging and biospy of the prostate 3 years ago. Survival data for these patients have been correlated with the clinical and histologic findings of 3 years ago. A negative biopsy was associated with a better prognosis than a positive one and clinical rectal examination of the treated prostate was a poor index of cancer control. The group of patients treated with a combination of endocrine and radiation therapy was associated with the highest proportion of negative biopsies.
Biopsy↗