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Biomedical subjects

M J McClure

Publications and source records attributed to M J McClure.

12 recordsLinked to original sources
PubMed2001

Radiological features of epiploic appendagitis and segmental omental infarction.

Epiploic appendagitis and segmental omental infarction are more frequently encountered with the increased use of abdominal ultrasound and Computed tomography (CT) in the radiological assessment of the patient who presents clinically with acute abdominal pain. Recognition of specific imaging abnormalities enables the radiologist to make the correct diagnosis. This is important, as the appropriate management of both conditions is often conservative. Follow-up imaging features correlate with clinical improvement.

Abdomen, Acute↗
PubMed2001

Perineural cysts presenting as complex adnexal cystic masses on transvaginal sonography.

OBJECTIVE: This study describes the sonographic features of sacral perineural cysts that initially presented as adnexal complex cystic masses on transvaginal sonography. CONCLUSION: Perineural cysts may have a complex cystic appearance, including septation and internal debris, on transvaginal sonography. The extraovarian, extraperitoneal, and posterior location on real-time sonography are suggestive features.

Adnexal Diseases↗
PubMed2000

Duplex Doppler ultrasonography of lower limb veins: detection of cardiac abnormalities.

AIM: We describe the detection of right sided cardiac abnormalities by Doppler ultrasonography of the lower limb veins. We also attempt to quantify the degree of tricuspid regurgitation (TR) by analysis of the femoral vein Doppler waveform (DW). MATERIALS AND METHODS: The DWs of the lower limb veins were examined in 276 patients over a 17-month period. The detection of abnormal pulsatile DW was compared with echocardiography on these patients. The reports of chest radiographs (CXR) obtained on 104 of the 276 patients were reviewed. RESULTS: Abnormal cardiac pulsatility of the DW was detected in nine patients (3.3%), with abnormally high retrograde velocity peak (RVP) recordings. These abnormal RVPs are compared to RVPs in a normal control group. The RVPs in the abnormal group revealed a statistically significant (Pearson's r = 0.9113) correlation with the degree of TR observed on echocardiography. All nine patients (100%) demonstrated cardiac enlargement on CXR compared to 16 of the 95 (16.8%) with a normal DW and available report of recently performed CXR. CONCLUSION: Doppler ultrasonography of lower limb veins is a frequently performed examination in most Radiology departments. We describe a simple, effective and reproducible ultrasound technique enabling detection of an underlying cardiac abnormality that may provide an estimation of the degree of TR. These important signs should alert the examining radiologist to the presence of an underlying cardiac dysfunction that may require further appropriate cardiac evaluation.McClure, M. J. (2000). Clinical Radiology 55, 533-536.

Adult↗
PubMed1995

Wildervanck's syndrome presenting as hemiparesthesia.

A 41-year-old male presented with recent-onset left hemiparesthesia, described as a "tingling numbness" of the upper extremity, torso, and face. History revealed a lifelong horizontal diplopia, neck stiffness, and left-sided hearing loss for 5 months. Examination revealed an ocular exam consistent with Duane's retraction syndrome, clinical and radiographic evidence of congenital fusion of C2 and C3 demonstrative of the Klippel-Feil anomaly, and a sensorineural hearing loss confirmed by audiometry. The diagnosis of Wildervanck's syndrome was made based on this classic triad of findings. A thorough evaluation has not yielded an objective explanation for the episodic hemiparesthesia. We present a patient exhibiting the classic triad of Wildervanck's syndrome, whose presentation is unique because hemiparesthesia has not previously been reported in association with this rare syndrome.

Adult↗
PubMed1992

Infant stimulation during hospitalization.

Stimulation is essential to the development of infants and children. They are developing skills related to gross motor, fine motor-adaptive, language, and personal-social functioning. Hospitalization can disrupt the developmental process for infants, even those without pre-existing developmental delays, if intervention is not provided. Hospitalized infants are often subjected to an overabundance of meaningless stimulation or understimulation. Nursing needs to insure provision of meaningful stimulation to help alleviate the effects of hospitalization. Parents and/or significant others need to be included whenever possible. A suggested infant stimulation program for hospitalized infants is presented. Practicality for the pediatric clinician facilitates easy intervention.

Child Development↗
PubMed1985

Characterization of a new model of GM2-gangliosidosis (Sandhoff's disease) in Korat cats.

We have detected a disorder in Korat cats (initially imported from Thailand) that is analogous to human Sandhoff's disease. Pedigree analysis indicates that this disease in an autosomal recessive disorder in the American Korat. Postmortem studies on one affected cat showed hepatomegaly that was not reported in the only other known feline model of GM2-gangliosidosis type II. Histologic and ultra-structural evaluation revealed typical storage vacuoles. There was a marked deficiency in the activity of hexosaminidase (HEX) A and B in affected brain and liver as compared to controls. Electrophoresis of a liver extract revealed a deficiency of normal HEX A and B in the affected animals. The blocking primary enzyme immunoassay verified the presence of antigenically reactive HEX present in affected cat livers in quantities slightly elevated with respect to the normal HEX concentration in control cats. In leukocytes, obligate heterozygotes had intermediate levels of total HEX activity with a slight increase in the percent activity due to HEX A. Indeed, 4 of 11 phenotypically normal animals in addition to four obligate heterozygotes appear to be carriers using this assay. Affected brain and liver compared with control brain and liver contained a great excess of bound N-acetylneuraminic acid in the Folch upper-phase solids; thin-layer chromatography showed a marked increase in GM2-ganglioside. In summary, we have characterized the pedigree, pathology, and biochemistry of a new feline model of GM2-gangliosidosis which is similar to but different from the only other known feline model.

Animals↗