PubMed Health⌕ Search

Biomedical subjects

M J Neal

Publications and source records attributed to M J Neal.

At least 91 records · Page 5Linked to original sources
PubMed1978

Isoguvacine, isonipecotic acid, muscimol and N-methyl isoguvacine on the GABA receptor in rat sympathetic ganglia.

The GABA-mimetic activities of 4 analogues muscimol, isonipecotic acid, isoguvacine and N-methyl isoguvacine have been examined at the GABA receptor in the rat isolated superior cervical ganglion. The depolarizing action of all 4 analogues could be selectively antagonized by bicuculline methochloride and isopropyl bicyclophosphate. Muscimol was the only analogue more potent than GABA (molar potency ratio = 5.08 +/- 0.707). The potency of isoguvacine was 0.23 +/- 0.026 and isonipecotic acid 0.011 +/- 0.0028. N-methyl isoguvacine was less than 0.001 GABA.

Animals↗
PubMed1978

Discrimination between descriptive models of L-glutamate uptake by the retina using non-linear regression analysis.

1. The uptake of labelled L-glutamate by the isolated rat retina was measured over a large range of external concentrations (1 micron to 1 mM). 2. The results obtained from measurements of the initial velocity of L-glutamate uptake at different concentrations did not follow simple hyperbolic kinetics. 3. The error structure of replicate velocity measurements was examined and found to be normally distributed and heteroscedastic. 4. Descriptive models were fitted directly to data, weighted by the invariance, using non-linear regression analysis. 5. The most suitable suitable descriptive model consisted of a saturable hyperbola (Vm = 285 n-mole.(g wet wt.)-1.min-1, Km = 252 micron) and a linear term (b = 0.45 min-1).

Animals↗