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Biomedical subjects

M J Ohm

Publications and source records attributed to M J Ohm.

10 recordsLinked to original sources
PubMed1978

Cervical-vaginal flora of immunosuppressed renal transplant patients.

The purpose of this investigation was to determine the endocervical microflora present in 25 renal allograft recipients hwo were receiving therapeutic dosages of azathioprine or cyclophosphamide and prednisone. The aerobic flora was similar to that found in other populations. However, these immunosuppressed patients had more different anaerobic species per culture than were found in most other populations. This was reflected in the more frequent isolation of many species of anaerobic bacteria, especially the anaerobic gram-negative rods. The clinician should be aware of these differences since they may be significant in regard to gynecologic or obstetric postoperative infectious morbidity in women using immunosuppressive medications.

Adult↗
PubMed1976

Aerobic and anaerobic flora of the cervix during pregnancy and the puerperium.

Comparison of species of bacteria isolated from patients with endometritis with species isolated from normal pregnant and nonpregnant women suggests that bacteria causing infections are indigenous to the genital tract. However, complete studies of the flora of pregnant women, especially anaerobic flora, are lacking. Aerobic and anaerobic cultures of the endocervix were obtained from women in all trimesters of pregnancy and at three days and six weeks post partum. The incidence of occurrence of each species of bacteria and the average number of different species per culture were determined for each period. The most prevalent organisms in each period were aerobic gram-positive rods and cocci and anaerobic gram-positive cocci. The average number of species of aerobic bacteria per culture remained approximately the same in each culture period. The average number of anaerobic species per culture decreased as pregnancy progressed, peaked on the third postpartum day, and at six weeks post partum returned to a level similar to that of the first trimester.

Bacteroides fragilis↗
PubMed1976

The effect of antibiotic prophylaxis on patients undergoing total abdominal hysterectomy. I. Effect on morbidity.

A prospective, double-blind study was conducted to evaluate the effect of cephalosporins on morbidity of women undergoing total abdominal hysterectomy. Each patient received a 5 day course of active drug or placebo beginning the night before surgery. Microbiologic studies, including culture and antibiotic sensitivities, were done on each patient pre- and postoperatively. Of the 46 women who received placebo, eighteen (39 per cent) were classified as morbid. Causes of morbidity included operative bed, wound, respiratory, or urinary tract infections. E. coli was the organism most frequently isolated. Of the 47 women who received cephalosporin prophylaxis, seven (15 per cent) were classified as morbid. The causes of the morbidity were often poorly defined, and cephalosporin-resistant organisms were recovered more often from these women than from those on placebo. There was no significant difference in length of hospital stay between women who received prophylaxis and those who did not.

Adult↗
PubMed1976

The effect of antibiotic prophylaxis on patients undergoing total abdominal hysterectomy. II. Alterations of microbial flora.

Preoperative cultures of the endocervix were taken on 93 women who subsequently underwent total abdominal hysterectomy and received a 5 day course of either prophylactic cephalosporins or placebo. Postoperative cultures of the vaginal apex were taken on 86 of these women 5 days after surgery, i.e. 1 day after the cessation of study medication. Comparisons of the preoperative and postoperative flora in both the active drug and placebo groups as well as comparisons between the postoperative flora of the drug group and that of the placebo group were made. Postoperative alterations of bacterial flora occurred whether or not the patient received prophylactic antibiotics.

Aerobiosis↗
PubMed1975

The effect of antibiotic prophylaxis on patients undergoing vaginal operations. I. The effect on morbidity.

A prospective, double-blind study was conducted to evaluate the effect of cephalosporins on morbidity in women undergoing vaginal hysterectomy. Each patient received a five-day course of an active drug or a placebo beginning the night before operation. Microbiological studies, including culture and antibiotic sensitivities, were done on each patient pre- and post-operatively. Of 23 women who received the placebo, 11 (48 percent) were classified as morbid. They had either an operative bed infection or a urinary tract infection. Only a small number of cephalosporin-resistant organisms were involved in these infections. Of the 25 women who received the cephalosporins, none (0 per cent) was classified as morbid. A small increase in the number of cephalosporin-resistant organisms (most notably Pseudomonas aeruginosa) was found postoperatively. Four patients were readmitted with pelvic infections after their original discharge. Microbiological data and a discussion of these infections are presented.

Adult↗
PubMed1975

The effect of antibiotic prophylaxis on patients undergoing vaginal operations. II. Alterations of microbial flora.

Preoperative and postoperative cultures of the upper vagina were taken from 48 women who underwent vaginal hysterectomy. They received a five-day course of either prophylactic cephalosporins or placebo. Comparisons of preoperative and postoperative flora in both the active-drug and placebo groups as well as comparisons between the postoperative flora of the drug group and that of the placebo group were made. Alterations of the bacterial flora occurred whether or not the patient received prophylactic antibiotics.

Adult↗
PubMed1975

Bacterial flora of the cervix from 100 prehysterectomy patients.

Although anaerobic bacteria are being reported more frequently as causes of pelvic infections, few investigators have carefully studied these organisms in the normal female genital flora. This study describes the aerobic and anaerobic flora of 100 women prior to their undergoing hysterectomy. Anaerobic organisms were isolated from 86 per cent of the cultures in combination with aerobic organisms. Of the anaerobes the gram-positive cocci were the most common isolates (154 isolates in 74 cultures). The anerobic gram-positive rods (41 isolates in 38 cultures) were second, followed by the anerobic gram-negative rods (32 isolates in 29 cultures) and the anerobic gram-negative cocci (16 isolates in 15 cultures). The gram-positive cocci were most prevalent aerobic organisms isolated (149 isolates in 85 cultures).

Adult↗