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Biomedical subjects

M J Perelman

Publications and source records attributed to M J Perelman.

5 recordsLinked to original sources
PubMed1992

Evaluation of cryopreserved allograft venous conduits in dogs.

We investigated the effects of cryopreservation, immunosuppression, and antibiotic treatment on the patency and histologic appearance of venous conduits in the arterial circulation. Twenty-eight dogs received arterial replacements with autograft vein, fresh allograft, and two types of cryopreserved allograft vein implanted into both carotid and both femoral arteries. All animals were given aspirin, and half were given cyclosporine. After 3 months the vein grafts were harvested. Patency and light, transmission, and scanning electron microscopic criteria were scored to evaluate quality of preservation of the endothelium, the appearance of rejection, and the effects of cryopreservation with and without antibiotic pretreatment. The results show that patency is not statistically different based on graft type or treatment modality. The histologic appearance among the various vein types was remarkably similar at 3 months, with the exception of a cellular infiltrate present most prominently in the fresh allografts and least in the fresh autografts. Cyclosporine, even at a low dose, decreased the incidence of cellular infiltration. Preservation of endothelium was generally good in the cryopreserved allografts both with and without antibiotic pretreatment. In general, the effects of cryopreservation, cyclosporine, and antibiotics ameliorated the effects of venous allografting into an arterial position.

Animals↗
PubMed1989

Aortic root replacement for complicated bacterial endocarditis in an infant.

We report the case of a 10-week-old girl with streptococcal aortic valve endocarditis that was resistant to medical management and complicated by aortic insufficiency, congestive heart failure, annular abscess, and a large periaortic pseudoaneurysm. She underwent successful aortic valve and root replacement (with coronary artery reimplantation) utilizing an aortic valve homograft (allograft). The patient recovered completely and was discharged 3 weeks postoperatively. To our knowledge, this is the youngest patient to receive an aortic homograft for bacterial endocarditis and annular abscess.

Aorta↗
PubMed1988

[Adaptation of the bronchi using rotation anastomosis].

Seventeen dogs were examined for experimental peculiarities of bronchial adaptation techniques and for effects such techniques may have on the formation and regeneration of anastomoses, following upper bilobectomy with sleeve resection of the primary bronchus. The difference in diameters of bronchus stumps to be interconnected was overcome by means of rotational anastomosis in twelve animals. The caudal stump was turned by 60 degrees (width of membranous part of cranial stump), and steps between sutures on the cranial stump were enlarged relative to the caudal stump. Also, the membranous wall of the lower lobar bronchus was pulled over the cartilagenous semicircle of the primary bronchus. The animals were kept under follow-up observation for one year maximum. Bronchological, radiological, and morphological checks were made at different postoperative intervals to obtain information about the condition of the anastomosis. Results have shown that in several cases rotational anastomosis can be recommended as a convenient and rational approach with no negative consequences to bridging gaps between bronchial diameters. The heterogeneous tissues of bronchial walls, following rotational anastomosis, were found to consolidate with each other within a period of time identical with that required by homogeneous tissue. Rotational anastomosis has been applied with good success to four patients.

Anastomosis, Surgical↗
PubMedDate not supplied

15-Deoxyspergualin and primate heart transplantation.

15-Deoxyspergualin is a synthetic polyamine that exhibits a novel spectrum of immunosuppressive activity in lower mammals. To define the clinical potential of this drug, we performed 25 abdominal heterotopic heart transplants in Macaca fasicularis. Donor and recipient pairs were selected from ABO-identical animals with negative erythrocyte crossmatches. All recipients received one dose of methylprednisolone sodium succinate at graft reperfusion. Five control recipients received no subsequent immunosuppression. Five recipients received high-dose 15-deoxyspergualin (7.5 mg/kg IM). Five recipients received low-dose 15-deoxyspergualin (2.0 mg/kg IM). Five recipients received cyclosporine (1.0 mg/kg IM). Five recipients received both 15-deoxyspergualin (2.0 mg/kg IM) and cyclosporine (1.0 mg/kg IM). Immunosuppressive agents were administered daily, beginning with the morning of operation, and were continued until the animal was killed or 30 days had elapsed. Graft function was assessed by daily palpation. Median graft survival among control recipients was 9 days (range, 6 to 34 days). At the dose used, cyclosporine alone did not influence either graft survival time (median survival, 13 days; range, 7 to 23 days) or rejection grade. Graft survival and rejection grade among recipients treated with low-dose 15-deoxyspergualin were not different from control recipients or those treated with cyclosporine alone (median survival, 10 days; range, 8 to 39 days). One recipient, killed on postoperative day 8, had an intraadominal abscess. In each of the recipients treated with high-dose 15-deoxyspergualin systemic toxicity developed, and the animal was killed when death appeared imminent, although graft contraction remained vigorous (median survival, 28 days; range 25 to 30 days).(ABSTRACT TRUNCATED AT 250 WORDS)

Alopecia↗