Biomedical subjects

M J Piña Vera

Publications and source records attributed to M J Piña Vera.

4 recordsLinked to original sources

PubMed1993

Decision analysis applied to the selection of angiotensin-converting enzyme inhibitors.

Decision analysis is applied to the group of angiotensin-converting enzyme inhibitors, in order to select those which should be included in the hospital formulary and to establish a research method which allows the reproduction of the process with new, related drugs. Captopril, enalapril and lisinopril were the alternatives considered. Evaluation criteria were efficacy, clinical experience, safety, dosage interval, hepatic bioactivation, interactions, dosage forms and cost. A relative weight was assigned through a survey among the hospital's staff. Each alternative was evaluated in relation to all criteria. Sensitivity analysis was applied to validate the method. Enalapril obtained the highest score, followed by lisinopril and captopril. The sensitivity analysis confirms this result. Enalapril is selected for the hospital formulary due to its higher score, although the differences between the three are very small.

Angiotensin-Converting Enzyme Inhibitors↗

PubMedDate not supplied

[Interstitial cystitis: drug therapy].

The present job reviews the etiology, clinical presentation, diagnostic and treatment of interstitial cystitis. An exhaustive revision is made of all the possibilities of pharmacological treatment with a special mention to the two major drugs: dimethylsulfoxide and pentosampolysulphate. A critical judgement of existing clinical trials is made. The conclusion indicates the need of more controlled experimental work in the future to allow a more objective determination of the most appropriate and effective therapy for these patients.

Cystitis↗

PubMedDate not supplied

[The quality control of a photoprotector bag against ultraviolet light].

The action of light on parenteral nutritional solutions may affect the stability of many of their ingredients. The aim of this study is to perform quality controls on a commercial photoprotective bag by quantifying the degradation of riboflavin in isotonic saline solution during forty-eight hours. Thirty solutions were prepared using 5 mg of riboflavin in 500 ml of saline solution. These were divided into three batches; one not protected from the light, one in a black bag and the third in a commercial bag. Samples were taken at 0 and 48 hours, and were analyzed by spectrophotometry. Solutions were prepared using 1.75 mg of riboflavin in 500 ml of saline solution. The same method was followed, and the samples were analyzed by fluorometry. The results were analyzed using the Student t test. The black bag was seen to be superior to the other two as a protector against ultraviolet light. There were no significant differences between the commercial bag and the non-protective bag.

Evaluation Studies as Topic↗

PubMedDate not supplied

[An evaluation of the effect of light on a commercial solution of amino acids for parenteral nutrition].

There are few studies on the stability of amino acids in solutions prior to mixing for parenteral nutrition, and even few studies which evaluate the contribution of light to their deterioration. The present study was carried out with the aim of becoming familiar with this parameter of stability in the working conditions of our Pharmacy Service. Two batches of Aminoplasmal L-10 were taken, one of which was subjected to direct low intensity sunlight and the other was maintained in the dark, as a control batch, for between 3-6 months. At the end of this time, complete aminograms were performed by ionic interchange chromatography. The measurements of concentrations of each amino acid were obtained for each batch. A Student T test was used to show that there were no significant differences between them after both 3 and 6 months. It was therefore concluded that the amino acid solution we had tested was maintained stable under the light exposure conditions of our Service after 6 months.

Amino Acids↗