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M J Pitout

Publications and source records attributed to M J Pitout.

34 records · Page 2Linked to original sources
PubMed1971

A comparative study on aflatoxin B 1 metabolism in mice and rats.

In vivo metabolic studies on rats and mice revealed a marked difference in the fluorescent compounds produced after ingestion of aflatoxin B(1). The mouse converted aflatoxin B(1) to three unknown fluorescent compounds, designated x(1), x(2) and x(3) and the known aflatoxin M(1), while the rat was only capable of producing aflatoxin M(1). The results suggested that metabolites x(1), x(2), x(3) and aflatoxin M(1) were not part of a major metabolic pathway, but produced independently. These unknown yellowish-green fluorescent compounds did not seem to be conjugated with sulphate or glucuronic acid.In vitro incubations of various mouse liver cell fractions with aflatoxin B(1) showed that metabolites x(1), x(2), x(3) and aflatoxin M(1), could only be produced by the microsomal fraction and that NADPH was needed as a co-factor. The differences in aflatoxin metabolism by mice and rats are discussed in relation to the apparent resistance of the mouse to the carcinogenic effects of this toxin.

Absorption↗
PubMedDate not supplied

Sialic acid in semen of normozoospermic men.

Good sperm motility in normozoospermic men was associated with high bound and total sialic acid (SA) and pyruvate concentrations in the seminal plasma, as well as high endogenous (sperm) pyruvate concentrations. The presence of sialidase in the seminal plasma was also demonstrated for the first time. The results suggest that SA is metabolized to pyruvate by a N-acetylneuraminic acid (NANA)-aldolase in the seminal plasma and that pyruvate subsequently serves as an energy source for sperm.

Humans↗