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Biomedical subjects

M J Pitt

Publications and source records attributed to M J Pitt.

9 recordsLinked to original sources

Rickets and osteomalacia are still around.

The terms rickets and osteomalacia describe gross, histologic, and radiologic abnormalities common to more than 50 diseases that vary in cause and clinical presentation. Rachitic and osteomalacic syndromes seen in current clinical practice usually are resistant to vitamin D forms and are most often caused by phosphate loss or 1,25(OH)2D deficiency, or both. Radiographic identification of rachitic or osteomalacic syndromes and accurate diagnosis of a particular cause is essential, as many patients' conditions can be improved or cured with proper therapy.

Adult

Imaging of the pelvis and hip.

Imaging is basic in the orthopedic evaluation of hip disorders. For optimal evaluation of these images, the orthopedic surgeon must not only correlate normal anatomy and pathology with radiographic findings, but must also be familiar with the newer modalities of CT, magnetic resonance imaging and ultrasound and the role and place of these studies in the evaluation of musculoskeletal disorders. This article correlates normal anatomy of the hip with these modalities and discusses the details of these techniques, particularly CT and MRI, that are pertinent to the orthopedic surgeon.

Epiphyses, Slipped

Thermographic, radionuclide, and radiographic detection of bone metastases.

The sensitivity of thermography to osseous metastases is compared to 99mTc bone scanning using the specificity of radiographic skeletal survey as proof of metastases. Thirty-five patients with suspected disease were selected for study. Bone scans detected 94.4% while thermograms detected 22.2%. Thermography proved quite insensitive to osseous metastases. Radionuclide bone scanning is the method of choice for the present.

Bone Neoplasms

Technetium-99m-diphosphonate accumulation in amyloid.

A well-documented case of multiple myeloma complicated by histologically demonstrable amyloidosis is presented. Technetium-99m-diphosphonate in the areas of amyloid deposition about the shoulders and hips is shown. This adds another dimension to the extraosseous sites without demonstrable calcification where accumulation of bone-seeking radiopharmaceutical can be observed. In patients where symmetrical uptake of such agents is noted in the periarticular soft tissue, particularly of the hips and shoulders, amyloidosis must become a diagnostic consideration. This is particularly true in patients presenting with undiagnosed arthralgia.

Amyloidosis