Bilateral sudden visual loss in Albright's syndrome.
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Biomedical subjects
Publications and source records attributed to M J Potts.
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Nineteen patients with thyroid eye disease were examined with magnetic resonance imaging using the Short Tau Inversion Recovery (STIR) sequence and compared with normal controls. The Signal Intensity Ratio (SIR) of each of the four recti was obtained by comparison with the signal intensity of the adjacent temporalis muscle. The SIR was compared with disease activity assessed using Werner's grading system, a clinical inflammatory score, and the range of extraocular movements. Results show that a high SIR is associated with a high index of disease activity. This technique is likely to prove useful in assessing disease activity and planning the management of thyroid eye disease, particularly with respect to immunosuppression.
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Cine magnetic resonance imaging (MRI) is a technique in which multiple sequential static orbital MRI films are taken while the patient fixates a series of targets across the visual field. These are then sequenced to give a graphic animation to the eyes. The excellent soft tissue differentiation of MRI, combined with the dynamic imaging, allows rapid visualisation, and functional assessment of the extraocular muscles. Good assessment of contractility can be obtained, but the technique does not allow study of saccadic or pursuit eye movements. We have used this technique in 36 patients with a range of ocular motility disorders, including thyroid-related ophthalmopathy, blow-out fracture, post-operative lost or slipped muscle, and Duane's syndrome.
Orbital chondrosarcomas are extremely rare and are usually an extension of tumours involving the paranasal sinuses. A unique case of dedifferentiated chondrosarcoma arising solely within the orbit is presented.
One hundred mothers who delivered infants at a rural community hospital between March and July 1990 were surveyed during their postpartum hospital stay to determine their opinions and expectations concerning constipation in infancy. Thirty-eight percent of multiparous mothers reported constipation in their previous children, which resolved with all home treatments given. Only 23% of the mothers reporting constipation mentioned this to their physicians. All mothers significantly underestimated stool frequency from ages birth to one week, relative to previously published norms. Mothers overestimated stool frequency at one week to one month, but this difference was not statistically significant. The most frequent description of constipation was inability to pass stool; pain was rarely mentioned. Most mothers agreed with the statement, "Constipation is dangerous for babies." Mothers reported learning about stool habits from previous personal experience, written materials, and their own mothers; impact of health-care professionals on their knowledge was minimal. The opinions and expectations of newly delivered mothers can be used to develop patient education and anticipatory guidance material to improve teaching and relieve parental anxiety about infant stool habits.
Few studies of the effects of clinical clerkship sequence on specialty choice have been performed, and results of such studies have been conflicting. The effect of the first clinical rotation on specialty choice has not been examined. Transcripts of 569 graduates of Michigan State University College of Human Medicine were reviewed to determine the sequence of required clerkships and ultimate specialty choices. Actual residency choices for the five required specialties were compared to the predicted numbers of specialists for the cohorts of students taking each clerkship as a first rotation. No significant differences from the predicted values were found. Our data support the contention that the sequence of medical school clerkships has no effect on ultimate specialty choice.
The EEC syndrome (ectrodactyly or lobster-claw deformity, ectodermal dysplasia, and cleft lip and palate) is a rare disorder with autosomal dominant inheritance, variable expression, and in some families lack of penetrance. We present the findings in five cases with emphasis on the ocular findings. Lacrimal surgery was performed on three patients with good results in each case. We also report the occurrence of spontaneous corneal perforation in two cases, a complication not previously recognised. The ophthalmic care of these patients must be pursued long-term, as progressive visual impairment may be the most disabling feature of the syndrome.
Direct immunofluorescence (DIF) techniques were compared with conventional cell culture for the diagnosis of ocular infections with Chlamydia trachomatis. The DIF test was found to have a sensitivity of 100% and a specificity of 97.5%. Of 178 patients studied, 19 patients (11%) were positive by DIF and 15 (8.4%) by conventional cell culture technique. Four patients who had previous treatment with chloramphenicol eye drops were negative by cell culture but positive by the DIF test. The DIF test is considered to be a rapid, accurate test with a number of advantages over culture techniques for the detection of C. trachomatis. The importance of appropriate referral of positive patients to prevent more serious sequelae due to C. trachomatis infection is discussed.
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OBJECTIVE: Our aim was to evaluate a novel means of assessing ocular motility disorders using MRI. MATERIALS AND METHODS: A GE image of the orbit was acquired in a set plane each time the patient fixed on a series of points spread across the field of view. The images were transferred in sequence to a video recorder to create a cineloop of ocular movement. The technique was used in 33 patients with a range of ocular motility disorders including thyroid eye disease, posttraumatic diplopia, and Duane syndrome. RESULTS: In addition to anatomical detail, functional information could be derived from motion of the globe, motion of the optic nerve, and contractility of individual muscles. This is of particular use to the ophthalmic surgeon in disorders of ocular motility following eye surgery. CONCLUSION: A method of recording eye movements using MRI is described that offers useful functional information in the evaluation of disorders of ocular motility.
In 1974, Michigan State University established the Upper Peninsula Medical Education Program (UP) to improve the physician supply in rural areas of Michigan by training students in a rural, practice-based setting. Practicing graduates of the program (N = 28) were surveyed by mail and their responses compared to a random sample of downstate MSU graduates (N = 57) with regard to practice location, specialty choice, hometown, and medical education and training. UP Program graduates showed a tendency to rural origin and chose rural practice and primary care specialties, especially family practice, more often than did their downstate colleagues. Responses of UP graduates suggested that rural residency locations would lead to increased numbers of rural practitioners. The rural UP Program has been successful to date in training medical students who ultimately pursue careers in rural primary medicine.