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Biomedical subjects

M J Reardon

Publications and source records attributed to M J Reardon.

99 records · Page 6Linked to original sources
PubMed1977

The activity of a benzothiopyranoindazole (IA-4 N-oxide) against Schistosoma mansoni infection in rhesus monkeys.

The prophylactic and therapeutic efficacies of IA-4 N-oxide against Schistosoma mansoni in rhesus monkeys (Macaca mulatta) have been evaluated. Ten monkeys were divided into 5 groups of 2 monkeys each. All monkeys were exposed to S. mansoni cercariae on day 0 and treatment groups were established as follows: untreated controls, oral prophylactic administration, intramuscular prophylactic administration, oral therapeutic administration, and intramuscular therapeutic administration. Analysis of parasitologic and pathologic criteria indicate that the compound is most effective when administered as a therapeutic regimen. Complete cures were effected in these monkeys. Prophylactic treatments resulted in a delay in onset of patency and reductions in fecal egg excretion, worm burdens, and tissue damage.

Animals↗
PubMed1976

Mesocestoides in the baboon and its development in laboratory animals.

Tetrathyridia of Mesocestoides sp. were recovered from three wild-captured African baboons. Active larvae were administered orally to laboratory-reared dogs, cats, rats and mice. Development in canine hosts was rapid and a high percentage of mature intact worms was recovered as early as 14 days post-exposure. The few worms recovered from the feline hosts were stunted and fragmented. No adult worm development occurred in the rats or mice. No significant clinical or pathological manifestations were exhibited in the primate or experimental laboratory hosts.

Animals↗
PubMedDate not supplied

Left ventricular pseudoaneurysm complicating mitral valve replacement: transesophageal echocardiographic diagnosis and impact on management.

Left ventricular pseudoaneurysm formation after mitral valve replacement, although infrequent, is a serious complication with potential catastrophic results. We describe a case of an anterobasal pseudoaneurysm compressing all branches of the left coronary artery, which was missed by initial transthoracic echocardiography and was well characterized with the transesophageal approach. Although the pseudoaneurysm was detected at contrast ventriculography, the transesophageal study provided new specific details regarding the exact site of origin of the pseudoaneurysm and its relationship to the coronary arteries that significantly influenced planning the surgical procedure and patient management.

Aged↗
PubMedDate not supplied

Improved results of carotid endarterectomy in patients with symptomatic coronary disease: an analysis of 1,546 consecutive carotid operations.

The significant risk of fatal myocardial infarction after carotid endarterectomy in patients with coronary disease long has been recognized. In 1,546 consecutive carotid endarterectomies performed in 1,238 patients over the last 10 years, angina pectoris was present in 17% (212/1,238) of patients; a further 32% (396/1,238) of patients were asymptomatic, but had a history of myocardial infarction. The perioperative mortality (30 day) in the 1,306 consecutive endarterectomies in 1,026 patients without symptomatic coronary artery disease was 1.5% (15/1,026 patients). Of the 212 patients with symptoms, 85 carotid endarterectomies were performed in 77 patients without prior coronary bypass operation with an operative mortality of 18.2% (14/77 patients). The remaining 135 patients had 155 carotid endarterectomies but were treated by either prior coronary artery bypass (84 patients) or simultaneous carotid endarterectomy and coronary artery bypass (51 patients) with an operative mortality of 3% (4/135 patients). The greatly improved survival in those patients with symptomatic coronary disease who had a coronary artery bypass prior to or at the same time as carotid endarterectomy, and the absence of permanent neurological deficit in the 51 of these 135 patients who had simultaneous carotid endarterectomy and coronary artery bypass suggests that significantly improved survival can be achieved after carotid endarterectomy in these high risk patients by the use of simultaneous coronary artery bypass surgery.

Adult↗
PubMedDate not supplied

Reducing the risk of aviator-multifunction display interface problems with human factor models and optimization design methods.

Multifunction display and control systems (MFDCSs) in modern cockpits use computer-generated graphics and symbology that have integrated and largely replaced the myriad discrete electromechanical flight instruments found in older aircraft. While much is known about the physical and visual properties of MFDCSs, less is known about which human factors are the most important for optimum design and use. Reports in the literature indicate that poor MFDCS design can adversely influence flight performance. However, current MFDCS content design methods do not quantify the relative importance of different cognitive and psychomotor factors. This article discusses the need for practical human factors-oriented MFDCS design tools to optimize the distribution of systems information and functionality. Such advances may lead to better designed MFDCSs that reduce aircrew workload and stress and improve flight performance during both routine and emergency procedures.

Aerospace Medicine↗