PubMed Health⌕ Search

Biomedical subjects

M J Rosenholtz

Publications and source records attributed to M J Rosenholtz.

13 recordsLinked to original sources
PubMed1994

Ischemic colitis related to cocaine abuse.

It is well recognized that cocaine use can be associated with serious cardiovascular complications, including myocardial infarction. Several case reports have recently linked the use of cocaine with ischemic events of the small bowel and colon. We report a case of ischemic colitis complicated by perforation in a 47-yr-old diabetic man which occurred after recreational cocaine use. The older age of the patient and underlying diabetes mellitus were unique aspects of our case, compared with others reported in the literature. The patient's history of cocaine use was not initially identified. After we obtained a negative arteriogram result, we went back to the patient and the information was revealed. The literature regarding intestinal ischemia related to cocaine and other drugs/medications is reviewed. The abuse of cocaine should be considered in the differential diagnosis of acute intestinal vascular insufficiency syndromes.

Cocaine↗
PubMed1988

Posttraumatic lobular squamous metaplasia of breast. An unusual pseudocarcinomatous metaplasia resembling squamous (necrotizing) sialometaplasia of the salivary gland.

Squamous metaplasia arising in nonneoplastic breast parenchyma is reportedly rare. We present a unique case which occurred following severe blunt trauma to the right breast of a 59-yr-old woman. The lesion contained sheets of squamous cells with a lobular growth pattern, bland cytology with few mitoses, and keratin and keratohyalin granules. It bore a striking resemblance to squamous (necrotizing) sialometaplasia of the salivary gland in that it exhibited lobular, pseudocarcinomatous growth. The patient has remained free of disease 49 mo after segmental resection of the lesion. Four previous cases of squamous metaplasia of the female breast have been reported, though none presented with a history of trauma or previous surgical manipulation. It is important to differentiate this entity from pure squamous cell carcinoma, and metaplastic change in ductal breast carcinoma, fibroadenoma, and other lesions. Breast aspiration biopsies revealing squamous cells cannot exclude carcinoma; thus, caution must be exercised.

Breast↗
PubMed1984

Leiomyosarcoma in the mediastinum presenting as superior vena cava syndrome.

The authors report a case of leiomyosarcoma in the mediastinum presenting with superior vena cava obstruction, and also demonstrate the aggressive nature of this tumor in spite of radiotherapy. Where technically feasible, surgery appears to be the treatment of choice. The pathologic and electron microscopic features of this tumor are also described.

Aged↗
PubMed1983

Prepubertal gynecomastia with lobules and acini: a case report and review of the literature.

The case of an 11-year-old boy with prepubertal gynecomastia is presented. Endocrine workup, including sex steroid and pituitary hormone concentrations, as well as chromosome analysis, was normal. Microscopy of the mastectomy specimen demonstrated, in addition to ductal proliferation and fibrosis, formation of lobules and acini, simulating female breast tissue. The authors report the fourth case with this histologic feature. Review of the literature identified 41 cases of prepubertal gynecomastia; associated or underlying conditions were: adrenal adenoma or carcinoma in nine cases, testicular tumor in two, 11-beta-hydroxylase deficiency in four, familial gynecomastia in two, tuberous sclerosis in two, and, in part overlapping, sexual precocity in four. Gynecomastia usually regressed after tumor removal or cortisol replacement therapy. Histologic examination of breast tissue was performed in 18 cases. Lobule and acinus formation was described in only three.

Breast↗