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Biomedical subjects

M J Sarriá

Publications and source records attributed to M J Sarriá.

12 recordsLinked to original sources

[Clinical tumoral size dissociation in acoustic neuroma: reality or measure distortion?].

INTRODUCTION: In this study we have analyzed (i) the audiometric frequencies more often affected in acoustic neuroma (AN), (ii) the percentage of patients presenting normal hearing and those with sudden hearing loss, (iii) if there is a correlation between tumor size and hearing loss, and (iv) the relationship between clinical and radiological parameters and audiological data. METHODS AND MATERIAL: Retrospective study of 81 patients undergoing surgical removal of a sporadic AN. RESULTS: The highest threshold in the tumor's ear was found at 8000 Hz, and the highest interaural difference at 4000 Hz. The percentage of patients presenting normal hearing and sudden hearing loss was 2.5% and 9%, respectively. No significant association was found between tumor size and hearing loss, preoperative facial palsy or Vth cranial nerve deficit. There was a significant association between the degree of hearing loss and Vth cranial nerve deficit, and between hearing loss and preoperative facial palsy. CONCLUSIONS: The association between hearing loss and Vth cranial nerve deficit, and between hearing loss and preoperative facial palsy is independent the size of the tumour.

Adolescent↗

[Diagnosis of intracranial facial schwannoma: clinical, and radiological factors, and the value of immunohistochemistry].

OBJECTIVE: To analyze the clinical, radiological, and pathological features which may be useful to differentiate intracranial schwannomas of the facial nerve from vestibular schwannomas. MATERIAL AND METHODS: A retrospective study of 91 patients undergoing surgery with a clinical suspicion of vestibular schwannoma is presented. Clinical and radiological features are analyzed. Immunohistochemistry for neurofilaments was performed in selected cases of unilateral vestibular schwannomas, bilateral vestibular schwannomas, and facial nerve schwannomas. RESULTS: Facial function was normal in 83% of patients with vestibular schwannoma. Both patients with facial schwannomas had preoperative House-Brackmann grade II facial function. MRI showed no main differences between facial and vestibular schwannomas. A positive immunostaining was found in unilateral vestibular schwannomas, bilateral vestibular schwannomas, and facial nerve schwannomas. CONCLUSION: There are no specific clinical, radiological, or pathological factors to accurately differentiate schwannomas of the facial nerve from vestibular schwannomas.

Adolescent↗

[Is hearing preservation feasible with the retrosigmoid approach?].

The main advantages of the retrosigmoid approach are fast and good visualization of the brainstem structures and the possibility to remove tumors of all sizes. Hearing preservation, although possible, is not always achieved. The aim of this study is to present our experience with the retrosigmoid approach for acoustic neuroma resection, emphasizing our hearing results. The notes of 56 cases of acoustic neuroma removed through a the retrosigmoid approach were reviewed. Tumor size ranged from 8 to 50 mm (mean 24 mm). Considering patients with preoperative serviceable hearing, postoperative serviceable and measurable hearing was achieved in 13.3% and 26.7% of cases respectively. No tumor recurrence occurred in our series. The retrosigmoid approach is a reliable surgical procedure for most vestibular schwannoma. However, hearing preservation results may be unsatisfactory and show wide differences depending on selection criteria and the hearing terminology used. Concerns about hearing preservation should not be the deciding factor for using this approach.

Adult↗

Facial electroneurography: results on normal humans.

Electroneurography (ENoG) is one of the tests recently introduced for the clinical analysis of facial paralysis. Right-left facial differences, test-retest variability and differences between the first and the last CAPs after 25 consecutive stimuli were studied in 24 normal subjects. Significant inter-subject right-left differences were not found. Intra-subject results show an average variation of 25 per cent in the amplitude between either side of the face. Test-retest variability is minimal both for the amplitude and for the latency (3.15 per cent and 1.9 per cent respectively). No differences in amplitude or in latency were found between the first and last compound action potentials gathered after 25 consecutive stimuli.

Action Potentials↗

Saccadic movements. A computerized study of their velocity and latency.

The mean velocity of the eye during the execution of a voluntary saccade can reach levels close to 400 degrees/sec, for amplitudes of 40 degrees. However, during the execution of these saccades, there are moments in which the eye develops velocities superior to 500 degrees/sec. The latency of the saccades diminishes when the stimuli are periodic, though it increases in the measure that the amplitude of the movement to be carried out increases. During the execution of the saccade the eye goes through a phase of rapid acceleration which occupies approximately a third of the total time used in the saccade. The rest of the time is spent in decreasing the velocity of the ocular movement. We feel that the velocities of all fast eye movements are not equal. Rather, the fast phases of nystagmus have a lesser velocity than do the saccades; though this last point is an opinion subject to future statistical confirmation.

Adolescent↗