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Biomedical subjects

M J Shikowitz

Publications and source records attributed to M J Shikowitz.

29 records · Page 2Linked to original sources
PubMed1987

Supraglottic hemangioma during pregnancy.

A 37-year-old woman, gravida 10, para 1-0-8-1, presented in her second trimester of pregnancy with complaints of frequent sore throats, change in voice quality, and recumbent dyspnea. These symptoms were noted initially during her previous pregnancy, and resolved after delivery. She was found to have a supraglottic hemangioma which occluded 40% of her upper airway. This lesion was noted to dramatically involute beginning at 36 weeks' gestation. The supraglottic hemangioma is a very rare cause of dyspnea in pregnancy. Its growth during pregnancy and regression postpartum is possibly related to the effects of estrogen and progesterone.

Adult↗
PubMed1986

Hematoporphyrin derivative therapy of papillomas. Experimental study.

Hematoporphyrin derivative has been shown to selectively localize in malignant tissues and chemically induced animal papillomas. It is a powerful photo-sensitizing agent that can cause destruction and death of tissues in which it has localized by the generation of singlet oxygen when activated by light of the appropriate wavelength (photodynamic therapy [PDT]). Laryngeal papillomas are rapidly growing benign epithelial neoplasms with a clinical course marked by multiple recurrences after surgical removal. Before considering PDT as a therapeutic modality in the treatment of this debilitating disease we developed an animal model for experimentation. Using the cottontail rabbit papillomavirus, sometimes referred to as the Shope papillomavirus, large cutaneous papillomas were induced on the backs of Dutch Belted rabbits. Following intravenous administration of hematoporphyrin derivative, PDT was delivered with white light. Marked regression of the papillomas was noted with replacement by normal hair-bearing skin. The clinical implications of this work to the control of laryngeal papillomatosis is discussed.

Animals↗
PubMed1986

Cardiac complications of suspension laryngoscopy. Fact or fiction?

A nonselective, prospective study of 100 consecutive patients undergoing suspension laryngoscopy was undertaken to observe the cardiac ischemic changes related to pharyngeal and laryngeal manipulation. Blood pressure, heart rate, rhythm, and cardiac response were monitored before, during, and after surgery. No significant changes were observed in normal, hypertensive, or high-risk patients. These findings differ from those previously reported.

Adult↗
PubMed1986

Bilateral vocal cord paralysis following endotracheal intubation.

Bilateral vocal cord paralysis following endotracheal intubation is an uncommon cause of respiratory obstruction. We report one case, adding to ten previously identified. We dissected eight human cadaver larynges and noted the path of the anterior ramus of the recurrent laryngeal nerve. It appeared to be particularly vulnerable to compression injury as it passed between the arytenoid cartilage and the thyroid lamina. This point was confirmed by histologic sections of intubated larynges.

Aged↗
PubMed1986

Squamous metaplasia in the trachea: the tracheotomized rabbit as an experimental model and implications in recurrent papillomatosis.

Squamous metaplasia following tracheotomy has been well documented. Most studies have dealt primarily with changes at--or adjacent to--the cuff site and have failed to evaluate its effect in the distal trachea. We have used rabbits as experimental models for the induction of tracheal squamous metaplasia, using uncuffed tracheotomy tubes. Rabbits were routinely killed 24, 36, 48, 72, 120, and 168 hours posttracheotomy, and the entire larynx, trachea, and main-stem bronchi were step-sectioned for histologic examination. Patchy areas of squamous metaplasia were found in all rabbits with tracheotomy equal to or longer than 48 hours. The metaplasia appeared to increase with time of intubation. Induction of squamous metaplasia (following tracheotomy as a contributing factor to the spread of laryngeal papillomatosis) is discussed.

Animals↗
PubMed1986

Sphenoid sinus mucocele masquerading as a skull base malignancy.

Mucoceles of the sphenoid sinus are rare. Only occasional reports have appeared in the medical literature since they were first described by Berg in 1889. The sphenoid sinus lies deep within the skull at the crossroads of 13 sensitive structures. The presence of a sphenoid sinus mucocele may be accompanied by a wide variety of signs and symptoms depending upon which of these structures are involved. The majority of these lesions are initially misdiagnosed as malignancies leading to increased patient morbidity and possible mismanagement. We present two cases of sphenoid sinus mucoceles which presented with a variety of neurological signs and symptoms. The radiographic findings were felt to be consistent with skull base malignancies. The diagnosis was corrected only after surgical exploration of the sphenoid sinus revealed a mucocele.

Diagnostic Errors↗
PubMed1985

Nasofrontal abscess following rhinoplasty.

Infections are the most common objective complication following rhinoplasty. They may remain localized, extend intracranially, or result in generalized septicemia. The most common infections involve the skin and subcutaneous tissues of the nose. We report an uncommon case of nasofrontal abscess following a rhinoplasty that required aggressive surgical and medical treatment.

Abscess↗
PubMed1984

Necrotizing fasciitis as a lethal complication of peritonsillar abscess.

Abscesses of the peritonsillar region rarely lead to serious complications. Incision and drainage, antibiotic therapy, and subsequent tonsillectomy is the accepted method of treatment. Two cases of fatal necrotizing fasciitis following peritonsillar abscess are presented. The entity of necrotizing fasciitis in the head and neck is discussed with respect to its presentation, diagnosis, and treatment.

Anti-Bacterial Agents↗