PubMed Health⌕ Search

Biomedical subjects

M J Simpkiss

Publications and source records attributed to M J Simpkiss.

10 recordsLinked to original sources
PubMed1985

Nebulised sodium cromoglycate in recurrently wheezy preschool children.

A double blind crossover study of nebulised sodium cromoglycate in 27 asthmatic preschool children was carried out over a one year period. All subjects had sufficiently severe asthma to have had at least one admission to hospital. The active treatment was sodium cromoglycate 20 mg (in 2 ml) administered by a nebuliser four times daily. Assessment was made by a diary card and clinical examination. Results were analysed in 24 subjects who completed the study. Statistical analysis allowed for order of treatment and seasonal effects. Significant results in favour of treatment with sodium cromoglycate were obtained for night cough, day activity, percentage of symptom free days, and overall severity of asthma. During active treatment there was no reduction in the rate of admissions to hospital or intravenous drugs used. The wheeze score during the week after an upper respiratory tract infection was not reduced during treatment with sodium cromoglycate. Nebulised sodium cromoglycate is a tedious prophylactic treatment for the young asthmatic child but is useful when other treatments have failed.

Aerosols↗
PubMed1975

A new cause of haemolytic anaemia in the newborn. A description of an unstable fetal haemoglobin: F Poole, alpha2-G-gamma2 130 trptophan yeilds glycine.

In a newborn twin with haemolytic anaemia an unstable fetal haemoglobin was found to be the cause. The anaemia improved spontaneously with the disappearance of the fetal haemoglobin. The new Hb F (alpha2gamma2) variant was shown to have a glycine at position 130 of the 146 residues of the gamma chain. This portion is inside the globin molecule and in all known normal globins it is occupied by a residue with a bulky hydrophobic side chain. Its replacement by glycine which has no side chain would be expected to cause instability. The human gamma-chains may either have a glycine or an alanine at position 136. Evidence is brought forward to suggest that in the abnormal chain position 136 is occupied by glycine.

Amino Acid Sequence↗
PubMedDate not supplied

Sound reward toys.

The multiplicity of disciplines involved in a comprehensive treatment and assessment centre provides fertile ground for the design of new apparatus of practical use in the field of therapy. Such projects encourage team work, are of considerable benefit to the patients and can lead to new approaches to problems. The construction and use of three sound reward toys for the diagnosis and treatment of speech disorders is described.

Biomedical Engineering↗