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Biomedical subjects

M J Toerien

Publications and source records attributed to M J Toerien.

6 recordsLinked to original sources

Pseudo-iniencephaly. A case report.

A case of congenital webbing with other congenital abnormalities is presented. Initial examination of the features of the case made a diagnosis of iniencephaly seem likely. However, further examination of the radiographs and the physical abnormalities demonstrated too few of the typical features, and the term pseudo-iniencephaly has been used to describe the case. The various aetiological possibilities are discussed, but it is clear that further research into webbing and its concomitant abnormalities would be necessary to provide the answers to the questions posed by this case.

Abnormalities, Multiple

The orbital muscle of Müller.

The orbital muscle consists of smooth muscle fibres interspersed with blood lacunae and is therefore both contractile and erectile. Contraction is under sympathetic control, whereas erection appears to be under parasympathetic (pterygopalatine) influence. Apart from its possible effect on the position of the eyeball in the orbit, the muscle seems to be mainly concerned with directing facial venous blood to or away from the cavernous sinus which acts as a heat exchanger for internal carotid blood.

Face

Cranial neural crest extirpation and cyclopian development.

Extirpation of cranial neural crest cells in presomite to 5 somite chick embryos produces monsters which in all essential respects are identical to human cyclopias. The primary lesion involves damage to the forebrain and consequently the inhibition of the nasal placode and nasal organ development as well as the destruction of the anterior neural crest cells, with the resultant absence of the nasal and interobital septa and of the facial dermal skeleton.

Abnormalities, Severe Teratoid