Biomedical subjects

M J Tyler

Publications and source records attributed to M J Tyler.

38 records · Page 3Linked to original sources

PubMedDate not supplied

New caerin antibacterial peptides from the skin glands of the Australian tree frog Litoria xanthomera.

The secretion of the skin glands of the 'orange-thighed frog' Litoria xanthomera contains seven peptides. One of these is the know hypotensive peptide caerulein. Two new peptides, caerin 1.6 [GLFSVLGAVAKHVLPHVVPVIAEKL(NH2)], and caerin 1.7 [GLFKVLGSVAKHLLPHVAPVIAEKL(NH2)] show antibacterial properties. Two other peptides lack the first two amino acid residues of caerins 1.6 and 1.7 and show no antibacterial activity. The identification of the peptides in Litoria xanthomera confirms that this species is related to Litoria caerula, Litoria gilleni and Litoria splendida but not as closely as those three species are related to each other.

Amino Acid Sequence↗

PubMedDate not supplied

The structures of the frenatin peptides from the skin secretion of the giant tree frog Litoria infrafrenata.

The granular dorsal glands of the giant tree frog Litoria infrafrenata contain five peptides including caerulein (a known neuropeptide), and four new peptides named franatins 1 (MH+ = 1140 Da), 2 (1423), 3 (2180), 4 (2493). The amino acid sequences of the frenatins are detailed: their structures do not correspond to those of peptides isolated from other amphibians or animals. Frenatin 3, Gly-Leu-Met-Ser-Val-Leu -Gly-His-Ala-Val-Gly-Asn-Val-Leu-Gly-Gly-Leu-Phe-Lys-Ser-(OH), has wide spectrum antimicrobial properties.

Amino Acid Sequence↗