Biomedical subjects

M J Tyrrell

Publications and source records attributed to M J Tyrrell.

22 records · Page 2Linked to original sources

PubMed1970

Correlation of degree of left ventricular volume overload with clinical course in aortic and mitral regurgitation.

The results of left ventricular volume studies using biplane angiocardiography are described in 20 patients with mitral regurgitation and in 27 patients with aortic regurgitation. In both lesions, a regurgitant fraction of over 60 per cent was likely to be associated with severe symptoms and most patients in this group required operation. End-diastolic volumes were higher in patients with aortic regurgitation and were tolerated with fewer symptoms than in the group with mitral regurgitation. Most (19/21) of the patients with low ejection fractions (<0.60) had either rheumatic valvular lesions or had had potassium citrate as a cardioplegic drug at previous heart operations. The possible myocardial effects of these factors are discussed. Left ventricular volume studies have proved useful in the assessment of valvular regurgitation by quantitating regurgitant flow and giving a measure of the relative importance of valvular and myocardial disease.

Adolescent↗

PubMedDate not supplied

Complex transposition with interrupted right aortic arch and partial Di George syndrome: successful palliation with combined medical and surgical therapy.

A five-day-old infant with transposition of the great arteries, ventricular septal defect, and an interrupted right aortic arch underwent successful balloon septostomy, pulmonary artery banding, and aortic arch repair. The infant also had abnormal facies with severe refractory hypocalcemia and depressed T-lymphocyte number and function believed to represent a partial Di George syndrome. The hypocalcemia resolved following treatment with a vitamin-D analogue, T-cell number increased, and T-cell function improved, but both remained subnormal.

Aorta, Thoracic↗

PubMedDate not supplied

Congenital complete heart block in an infant with free plasma carnitine deficiency.

A newborn male presenting with congenital complete heart block was found to have low levels of free plasma carnitine. Among the many complications of carnitine deficiency is a structural disruption of myocardial tissue. A deficiency of carnitine may be causally related to the presence of cardiac dysrhythmias in this patient on the basis of mechanical disturbance to the cardiac conducting system.

Acidosis↗

PubMedDate not supplied

Elective oro-tracheal intubation to diagnose sleep apnea syndrome in children with Down's syndrome and ventricular septal defect.

Three children with Down's syndrome, ventricular septal defect, pulmonary hypertension and clinical evidence of upper airway obstruction had the trachea electively intubated while pulmonary artery pressures were monitored. In two, the pulmonary pressures immediately decreased and systemic arterial oxygen saturations increased. Both of these children showed dramatic clinical improvement after tonsillectomy. These cases indicate that elective tracheal intubation is a valuable diagnostic procedure to demonstrate the role of upper airway obstruction in the maintenance of reversible pulmonary hypertension in children with Down's syndrome and right to left shunts.

Airway Obstruction↗