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Biomedical subjects

M J Walsh

Publications and source records attributed to M J Walsh.

120 records · Page 7Linked to original sources
PubMedDate not supplied

A randomized, placebo-controlled clinical trial on the efficacy of chiropractic therapy on premenstrual syndrome.

OBJECTIVE: To evaluate the efficacy of chiropractic therapy on the treatment of symptoms associated with premenstrual syndrome. DESIGN: A prospective, randomized, placebo-controlled, crossover clinical trial. SETTING: Multicenter private clinics. SUBJECTS: Twenty-five subjects with diagnosed premenstrual syndrome (with a Moos premenstrual syndrome questionnaire plus daily symptom monitoring). INTERVENTION: After randomization, 16 of the subjects received high-velocity, low-amplitude spinal manipulation plus soft tissue therapy 2 to 3 times in the week before menses for at least 3 cycles. The remaining 9 subjects received a placebo treatment with a spring-loaded adjusting instrument wound down for minimum force. After a 1-cycle washout, the 2 groups changed over. OUTCOME MEASURE: Daily rating of symptom level, comparing total scores for premenstrual week with baseline for treatment and placebo phases. DATA ANALYSIS: The data were analyzed with paired Student t tests and Wilcoxon signed rank tests, with the statistical significance set at P < .05. RESULTS: There was a significant decrease in scores after treatment compared with baseline scores (P = .00001) and a statistically significant decrease in scores for the treatment phase compared with the placebo (P = .006). For group 1 (n = 16), there was a significant decrease in scores after treatment compared with baseline scores (P = .0001) and a statistically significant decrease in scores for the treatment phase compared with the placebo (P = .041). For group 2 (n = 9), there was a significant decrease in scores during treatment compared with the baseline (P = .01); however, there was no difference at the P = .05 level between treatment and placebo scores. CONCLUSIONS: Within the limitations of the study, the results support the hypothesis that the symptoms associated with PMS can generally be reduced by chiropractic treatment consisting of adjustments and soft-tissue therapy. However, the role of a placebo effect needs further elucidation, given that the group receiving the placebo first, although improving over the baseline, showed no further improvement when they had actual treatment.

Adult↗
PubMedDate not supplied

A signal analysis approach to rat sleep scoring instrumentation.

Automated rat sleep analysis focuses on the statistically regular waveforms of the EEG, such as theta and delta rhythms. Such stochastic processes can be quantified in several manners. Time domain statistics such as auto- and cross-correlations produce outputs that are difficult to use and are best performed in software. Frequency domain statistics like spectral density accurately quantify the sleep state by power-frequency distributions but also require sophisticated computer processing. Continuous frequency analysis, using pass-band filtering, accurately measures signal power in an on-line fashion and employs relatively inexpensive hardware to estimate power by integrating the square of the signal. This method differs substantively from other previously reported systems which rely on signal amplitude analysis. Comparison of this system with a human scorer indicates high degrees of validity and reproducibility.

Animals↗
PubMedDate not supplied

Immediate and follow-up results of coronary angioplasty--lessons for the future.

In a series of 129 patients having coronary angioplasties in St. James's Hospital in 1989, the average age was 54.8 (30-77 years). There were 102 (79%) men and 27 (21%) females. Clinical indications were unstable angina 62, stable angina 26, post myocardial infarction 39 and asymptomatic ischaemia 2. The distribution of coronary disease was single vessel 62%, double vessel 28%, triple vessel 7% and previous coronary bypass surgery 3%. Only 10 patients had more than one vessel dilated. Primary success was achieved in 119 (92%), there were no deaths, 3 patients had abrupt closure of the vessel during angioplasty and sustained a nonfatal myocardial infarction, 1 patient required urgent bypass surgery and 2 patients had peripheral vascular complications requiring surgery. There were 6 failed angioplasties, 4 of which had chronic total occlusion. At a mean follow-up of 5.3 months, 85 patients had no symptoms, 34 had angina, 2 developed myocardial infarction and 1 died suddenly at 5 months. Repeat angiography was performed in 96 (79%) patients. At follow-up, no symptoms were present in 69% of those with single vessel disease and 70% of multivessel disease. Of those who had more than one vessel dilated in multivessel disease, 80% were asymptomatic (P = NS). There were 11 patients with initial total occlusion at presentation, 4 had failed angioplasties, 5 recurrent angina of which 4 reoccluded and 1 restenosed and only 2 were asymptomatic and without restenosis. Angioplasty was performed with primary success (92%) and follow up results (70% asymptomatic). Those with single or multivessel disease had similar clinical outcome, favouring the use of target vessel angioplasty. Long term results following angioplasty of chronic total occlusions were poor and suggests the need for additional treatment.

Angioplasty, Balloon, Coronary↗
PubMedDate not supplied

Dietary purine nucleotides and the gastrointestinal tract.

There is a growing body of research that demonstrates a role for dietary nucleotides, the building blocks of RNA and DNA, during intestinal development, turnover, and repair. There is evidence that the effects of purine nucleotides may be mediated through intestinal gene transcription and, more specifically, through the action of transcription factors that, at least sometimes, are directly related to nutrition. Some of the suggested specific roles for dietary nucleotides include the enhancement of the normal host defense system, effects on neonatal lipid metabolism, and influence on iron bioavailability. This review focuses on the potential role of dietary (purine) nucleotides in the maintenance of intestinal integrity and reviews potential mechanisms for these effects.

Animals↗