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Biomedical subjects

M Jakobsson

Publications and source records attributed to M Jakobsson.

23 records · Page 2Linked to original sources
PubMed1987

Misonidazole combined with radiotherapy in the treatment of non-small cell lung cancer. A randomized double-blind trial.

Forty-one patients with inoperable non-small cell lung cancer were randomized to receive irradiation therapy 45 Gy in ten fractions over eight weeks, plus either placebo or misonidazole 1.2 g/m2 orally on treatment day. The irradiated area was the primary tumour. Twenty-one patients received misonidazole and 20 received placebo. Minimal observation time for the study was 36 months. No clear difference was observed in the pattern of relapse between the groups. 43% of the patients in the misonidazole group attained a complete response (CR) or partial response (PR) as compared with 65% in the placebo group. Median survival time was twelve months in the misonidazole group and 14 months in the placebo group.

Aged↗
PubMedDate not supplied

The effect of surgery, radiation therapy, and combined radiation therapy and chemotherapy on immunocompetence in patients with lung carcinoma.

The immunologic status of 59 patients with lung carcinoma was determined by analysis of peripheral venous blood samples. The following tests were performed: total leucocyte and lymphocyte counts, the number of acid alpha-naphthyl acetate esterase (ANAE) positive cells (T-cells), and phytohaemagglutinin (PHA) and tuberculin (PPD) transformation tests. The patients were divided into three treatment groups: a surgery group (S), a radiation therapy group (R), and a combined cytostatic and radiation therapy group (C). A follow-up was carried out 4 to 6 months after treatment. The therapeutic measures, resection, irradiation, and chemotherapy, produced a decrease in the total leucocyte and lymphocyte counts, in the number of T-cells, and in the leucocyte transformation response to PPD. In the surgically treated group the decrease was transient. In the groups treated with radiation therapy and combined cytostatic and radiation therapy the values remained low throughout the follow-up. The lymphocyte response to PHA was not altered in any of the groups during initial treatment or follow-up. The results did not suggest a correlation between the immunologic parameters used and the stage and histologic type of lung cancer. The tests were of no clinical value in the determination of the individual prognosis.

Adult↗
PubMedDate not supplied

Fentanyl patches for the treatment of pain in dying cancer patients.

It has been claimed that fentanyl patches are less suitable for elderly patients and for patients who are terminally ill and dying. In a retrospective survey of 205 cancer patients who died within the hospital-based home care in Norrköping, Sweden between January 1997 and June 1998 we identified 34 patients who had used fentanyl patches. 30 patients were possible to evaluate for the analgesic efficacy of transdermal fentanyl. 18 out of 30 patients were treated with fentanyl until time of death. The estimated efficacy was good or moderate in 93% and 88%, respectively, of patients younger or older than 65 years of age.

Administration, Cutaneous↗
PubMedDate not supplied

Mammographic and palpation findings in the irradiated spared breast.

Between 1983 and 1987, 22 women underwent breast-preserving treatment for T1 (n = 19) or T2 (n = 3) cancer. Axillary surgery was performed in 17 patients and axillary node "sampling" in one patient, while 4 patients had no axillary surgery. Radiotherapy was begun no later than six weeks after operation. The patients had the first post-treatment follow-up examination at 1 month to 41 months after irradiation. Six of the patients had more than one follow-up examination. According to the length of the follow-up period, there were two different groups of patients. Fourteen patients had the first follow-up examination at 1 month to 10 months after completion of radiation treatment. Eleven breasts (79%) had solid consistency as well as radiological edema. Six of the breasts had signs of severe edema seen during the first 6 months. At the second or third examination, if made after 10 months, the signs of edema decreased or disappeared. Eight patients examined for the first time at 12 to 41 months after radiation treatment had no radiological signs of breast edema and only 3 of the breasts were solid. The present results suggest that post-treatment mammograms are not useful during the first 6 months after irradiation and that the value of palpation is limited to at least 10 months; in selected patients these periods can be considerably longer.

Breast↗