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Biomedical subjects

M Jarema

Publications and source records attributed to M Jarema.

At least 19 recordsLinked to original sources
PubMed2006

Psychiatry in selected countries of Central and Eastern Europe: an overview of the current situation.

OBJECTIVE: To review the current status of psychiatry in selected countries of Central and Eastern Europe: Bulgaria, Croatia, Czech Republic, Hungary, Poland, Romania, Russia, Slovakia, and Slovenia. METHOD: A group of psychiatrists from the region evaluated the status of psychiatry at the end of 2004 based on data from their countries and information available on WHO homepages. RESULTS: There is a shift from traditional in-patient facilities towards out-patient and community services as evidenced by a decreasing number of hospital beds. Economic pressures affect the financing of psychiatric services, and reimbursement for novel psychotropics. Political changes were followed by updated legislation. Psychiatric training, pre-, postgraduate and continuous medical education, are gradually being transformed. Scientific output as measured by publications in peer-reviewed journals has been significantly lower than in the West. CONCLUSION: The major changes in the period of transition documented in the review pose new challenges for psychiatry.

Bulgaria↗
PubMed2004

Healthcare resource utilization during 1-year treatment with long-acting, injectable risperidone.

BACKGROUND: Schizophrenia is associated with disproportionately high costs, mainly due to hospitalization rates. This study assessed healthcare resource use in patients with schizophrenia and schizoaffective disorder during treatment with long-acting risperidone. METHODS: Patients (n = 397 [inpatients, 24%; outpatients, 76%]) receiving stable doses of an antipsychotic for >or=4 weeks were eligible to enter this 1-year, open-label study. Following a 2-week run-in period (oral risperidone 1-6 mg/day), patients received intramuscular long-acting risperidone (25 or 50 mg modal dose) every 2 weeks. Healthcare resource use in the previous 12 weeks was assessed at baseline and 12-weekly intervals. RESULTS: Patients needing hospitalization decreased significantly and continuously from 38% during the 12 weeks before study entry to 12% during the last 12 weeks. Mean hospitalization length during the study was 30.5 days (outpatients, 4.9 days; inpatients, 110 days). This included 28 patients (7%) who remained in hospital throughout the study. During treatment, 71% of those hospitalized at baseline were discharged. Partial hospitalization decreased significantly from 7% of patients during the 12 weeks before treatment to 3% during the last 12 weeks. Outpatient consultations also decreased significantly from 70% of patients to 30% in the first 12 weeks of treatment and remained stable thereafter. Only 9% of patients required an emergency room visit; mostly for non-psychiatric conditions. CONCLUSION: Healthcare resource use is significantly reduced in patients with stable schizophrenia or schizoaffective disorder receiving long-acting risperidone. It is highly likely that these reductions will decrease healthcare costs in patients receiving long-acting risperidone.

Adult↗
PubMed1996

[The evaluation of radiotherapy in the treatment of epidermoid carcinoma of the oral cavity].

An effect of radiotherapy, in 442 patient presented with epidermoid carcinoma of the oral cavity was studied. No significant prolongation of life-span was observed in patients subjected to radiotherapy both prior and after surgical procedure. Reoccurrence of carcinoma was less likely and appeared later in patients treated with radiotherapy than in patients subjected only to surgery.

Carcinoma, Squamous Cell↗
PubMed1991

The predictive value of psychopathological subclassifications for the neuroleptic treatment outcome in schizophrenia.

In the group of 58 schizophrenic patients who fulfilled the DSM-III-R criteria for schizophrenia, various subgroups have been identified according to the DSM-III-R subdivision of schizophrenic types, the DCR classification of systematic, nonsystematic schizophrenia and cycloid psychosis, as well as positive/negative symptoms of schizophrenia. All patients underwent therapy with one neuroleptic from four different neuroleptic groups. Some significant differences between the subgroups in respect to sociodemographic data were found. The DCR subdivision of patients revealed the majority of meaningful data regarding the predictive validity of psychopathology for the outcome of the neuroleptic treatment.

Adult↗
PubMed1990

[Advances in the diagnosis of Alzheimer's disease].

Alzheimer's disease is diagnosed ever more frequently and this requires more precise clinical and laboratory diagnostic methods. The authors discuss the diagnostic criteria and principles of diagnosis in this disease. Neuropathological lesions are described which are required for reliable diagnosis of the disease. Much attention is given to neuroradiological methods, including nuclear magnetic resonance and positron emission tomography.

Alzheimer Disease↗
PubMed1980

[Diagnosis of internal hydrocephalus using echoencephalography and computerized tomography of the brain].

Using computer tomography and echoencephalography 20 subjects with normal pattern of the lateral ventricles and 20 patients with dilatation of these ventricles were studied. The patients were hospitalized in the Neurology Department of the Vienna University. On CT scans the distance between the anterior horns and heads of the caudate nuclei, and cranial width were measured and appropriate indices were calculated. In Echo-EG the position of the temporal horn was established and the cerebral pallium index was calculated. It was found that different indices in CT examination differ in subjects with normal lateral ventricles and in patients with internal hydrocephalus. In cases of hydrocephalus the index of the caudate nucleus was greater and the index of the anterior horns was smaller. The per cent indices in these cases were higher than in subjects with normal ventricles. In the patients with hydrocephalus the index of cerebral pallium calculated from Echo-EG was greater than in subjects with normal ventricles. Both diagnostic methods are regarded as useful for evaluating internal hydrocephalus, especially since they are non-invasive.

Adolescent↗
PubMed1976

lac repressor: 3-fluorotyrosine substitution for nuclear magnetic resonance studies.

This paper describes the isolation of 3-fluorotyrosine-substituted lac repressor, and its 19F nuclear magnetic resonance spectrum. From the spectrum, one can conclude that for each of the four identical subunits of the repressor there are four or five surface tyrosines, two buried or internal tyrosines, and one tyrosine with an phenolic group ionized or involved in a hydrogen bond. Conditions are described that can be used for the 3-fluorotyrosine substitution of a variety of Escherichia coli proteins for 19F nuclear magnetic resonance studies.

Bacterial Proteins↗