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Biomedical subjects

M Javed

Publications and source records attributed to M Javed.

7 recordsLinked to original sources
PubMed1995

Familial hemiplegic migraine and autosomal dominant arteriopathy with leukoencephalopathy (CADASIL).

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a recently described familial cerebrovascular disorder shown to map to chromosome 19q12. Familial hemiplegic migraine has also been shown in some families to map close to the CADASIL locus. The fully developed CADASIL phenotype consists of recurrent strokes developing in the fourth decade, progressing to a pseudobulbar palsy, spastic quadriparesis, and subcortical dementia. In an Irish family 15 members were fully investigated by magnetic resonance scanning; 10 had typical magnetic resonance features of CADASIL. Five members of this family had familial hemiplegic migraine and 4 of these had magnetic resonance evidence of CADASIL. Two other members had migraine with and without aura as a presenting clinical symptom of CADASIL. This disorder has been shown by linkage analysis to map to the CADASIL locus at chromosome 19. The phenotype at presentation of CADASIL in this family was variable and age related and included familial hemiplegic migraine, migraine with and without aura, transient ischemic attacks, strokes, and spinal cord infarction. This family study increases our understanding of the spectrum of clinical manifestations of this underrecognized familial cerebrovascular disorder.

Adult↗
PubMed1995

Do alpha-blockers have a role in lower urinary tract dysfunction in multiple sclerosis?

Lower urinary tract dysfunction is a major cause of morbidity in patients with multiple sclerosis. alpha 1-Adrenergic receptors are present at the bladder neck, where increased tone may be responsible for urinary retention and diminished flow rates. A randomized placebo controlled study was designed to test the hypothesis that blockade of these receptors using the selective alpha 1-adrenergic receptor antagonist indoramin would improve bladder emptying in patients with multiple sclerosis. Peak and mean urinary flow rates, residual volume and symptom score were evaluated at trial entry and again after 4 weeks in 18 men with multiple sclerosis. There was a mean 41% improvement in peak flow rate in the actively treated group compared with a 7.4% deterioration in the placebo group (p < 0.05). Residual volume improved in both groups. Patients taking indoramin reported a greater improvement in urinary symptoms. Modulation of the alpha 1-receptor may have a role in the management of lower urinary tract dysfunction in multiple sclerosis.

Adrenergic alpha-Antagonists↗
PubMedDate not supplied

Superficial siderosis of the central nervous system.

Two patients with superficial siderosis of the central nervous system are reported. Both developed progressive deafness over many years; one with associated anosmia and partial seizures; the other with progressive ataxia and diplopia. The cerebrospinal fluid was xanthochromic in one and the protein was raised in both. Magnetic resonance imaging revealed a hypodense rim around the eighth cranial nerve, cerebellum, brain stem and spinal cord. Despite extensive investigations the cause of the superficial siderosis in both patients remains undetermined.

Adult↗
PubMedDate not supplied

The incidence of non ulcer dyspepsia and its response to treatment.

BACKGROUND: This study was undertaken to identify Non Ulcer Dyspepsia (NUD) in young patients presenting with peptic ulcer like symptoms. Their response to treatment was also determined. METHODS: 100 patients between the ages of 20-40 of both sexes were included in the study. Investigations done were Chest X-ray Plain Abdominal X-ray, ECG, ESR, LFTs Amylase Abdominal Ultrasound and upper GI endoscopy. All patients then received 6-week therapy with Omeprazole and Helicobacter Pylori eradication with Clarithromycin and Tinidazole. RESULTS: NUD was by far the most common cause (59%) in both the sexes. Response to therapy was unsatisfactory. CONCLUSIONS: This relatively newly discovered clinical entity should be kept in mind while dealing with patients presenting with refractory dyspeptic symptoms.

Anti-Bacterial Agents↗
PubMedDate not supplied

Sneddon's syndrome--clinical course and out-come.

Five patients presented with Sneddon's syndrome characterised by cerebral infarction, livedo reticularis, hypertension, epilepsy and a progressive dementia. Two patients had raised anticardiolipin antibody titres. The clinical symptoms and immunological disturbance in Sneddon's syndrome and the antiphospholipid syndrome are similar, and may indicate the importance of immune mediated thrombosis in Sneddon's syndrome.

Adult↗