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Biomedical subjects

M Jha

Publications and source records attributed to M Jha.

11 recordsLinked to original sources
PubMed2001

Clinical appraisal of Ascaris lumbricoides, with special reference to surgical complications.

Over a period of 4 years (January 1993-December 1997), 509 patients were treated for abdominal colic with or without intestinal obstruction and a history of passage of adult roundworms either in the stool or in vomitus. All patients were below the age of 10 years, the youngest 6 months old, and were treated successfully with antispasmodics and normal saline enemas. When the pain subsided, an anthelminthic drug was given. Of 209 patients admitted to the hospital, 105 responded to conservative management and 104 (50%) required surgical intervention. The procedures included squeezing out of worms, resection and anastomosis, and treatment of other pathologies like acute appendicitis, tubercular stricture of the small intenstine, etc. Five patients died in the postoperative period due to various complications. There were no deaths among those treated by conservative management. Early recognition of the condition can prevent serious surgical complications and morbidity.

Animals↗
PubMed2000

Usability issues in developing a Web-based consumer health site.

ClinicalTrials.gov is a Web-based system intended for a diverse audience, including patients, family members and other members of the public. Throughout the system design and development process, our decisions have been driven by usability concerns. We first describe the overall design of the site, including the home page, which provides a site overview and rapid access to the information contained within it. Next we discuss the data presentation format which has been standardized in spite of data coming to us from many different sources. We provide a detailed description of the search and browse features that are intended to simplify the complexities of medical terminology and support information discovery. We conclude with a review of our evaluation activities and future plans.

Clinical Trials as Topic↗
PubMed1999

Pregnancy and cirrhosis of the liver.

Pregnancy in patients with cirrhosis of the liver is uncommon. We reviewed 9 pregnancies in 7 patients with cirrhosis. One patient conceived within 1 month of diagnosis and in another the disease was diagnosed during the index pregnancy. Four patients has associated portal hypertension and 1 of them conceived after lienorenal shunt. Complications associated with these pregnancies were jaundice (1) jaundice plus ascites (2) and gastrointestinal bleeding (1). In 2 patients endoscopic sclerotherapy was done during the index pregnancy. The incidence of preterm delivery was 50% (4 of 8) and the majority (75%) occurred in pregnancies where associated complications were present. There was 1 maternal death in the postpartum period due to fulminant hepatic failure.

Adult↗
PubMed1983

Cellular and histochemical characteristics of osteoid formed in experimental fluoride poisoning.

The present study on the cellular and histochemical characteristics of osteoid formed in iliac crest bone during fluoride poisoning in rabbits was carried out as there is no information available to date either on its structural or biochemical characteristics. Osteoid formation in bone is prevalent both in fluorosis and in sodium fluoride therapy for osteoporosis. The report provides evidence which indicates that fluoride induces osteophytic activity leading to the formation of cartilagenous loci (fibrocartilage) in bone, the matrix of which is loaded with glycosaminoglycans (GAG) and proteoglycans. The occurrence of dermatan sulphate is demonstrated histochemically. Accumulation of dermatan sulphate in the cartilagenous matrix possibly prevents the normal process of mineralization.

Animals↗
PubMed1982

Age-related changes in pyridinoline content of rabbit collagen.

The age related changes in the content of pyridinoline were followed for collagen from rabbit muscles. Pyridinoline content of the muscle collagen in 2-week-old rabbits is very low and increases markedly with growth of the animals. However, it decreases after maturation in cardiac muscle but not in red & white muscle. Pyridinoline may serve as an interesting index for aging in connective tissue.

Aging↗
PubMed1982

Excessive ingestion of fluoride and the significance of sialic acid: glycosaminoglycans in the serum of rabbit and human subjects.

The levels of sialic acid and glycosaminoglycans were explored in the sera of rabbit and human subjects who ingested fluoride and had clinical manifestation of fluorosis. Changes observed in the level of these chemical constituents in sera possibly reflect changes occurring in calcified and noncalcified tissues due to fluoride intoxication. The ratio of sialic acid content vs glycosaminoglycans revealed there was a 50% reduction in rabbit and human sera. The test is recommended for evaluating the prognosis of fluoride poisoning/fluorosis.

Adolescent↗
PubMedDate not supplied

Urinary excretion of glycosaminoglycans, hydroxyproline and hydroxylysine in rabbits after excessive ingestion of fluoride.

Urinary levels of glycosaminoglycans (GAG) and hydroxyproline from normal and fluoride treated rabbits were estimated. The hydroxylysine content of serum and urine of rabbits after excessive ingestion of fluoride was also investigated. There was a progressive decrease in GAG content, reduction in hydroxylysine, whereas the hydroxyproline content was increased after fluoride ingestion. Enhanced hydroxyproline in urinary excretion is due to collagen breakdown after fluoride ingestion. The reduction in hydroxylysine content is due to reduced collagen cross-link formation. The report suggests the possibility of using the urinary levels of GAG or hydroxyproline or hydroxylysine as an index of fluoride intoxication.

Animals↗